Crystalline forms of tenofovir dipivoxil fumarate
The present invention relates to a crystalline form of tenofovir dipivoxil fumarate, a crystalline composition and a pharmaceutical composition comprising the crystalline form, and also to a process for preparing the same and the use for prophylaxis or treatment of a disease associated with a viral infection. The crystalline form has an X-ray powder diffraction pattern using Cu-Kα radiation, expressed in terms of lattice spacing “d” comprising peaks at about 18.4714 Å, 5.0350 Å, 4.6380 Å, 4.5347 Å, 4.3838 Å, 4.2874 Å and 3.6304 Å.
1. A crystalline form of tenofovir dipivoxil fumarate, having an X-ray powder diffraction pattern using Cu-Kα radiation, expressed in terms of lattice spacing “d” comprising peaks at 18.4714Å, 5.0350Å, 4.6380Å, 4.5347Å, 4.3838Å, 4.2874Å and 3.6304 Å.
2. The crystalline form of claim 1 , having an X-ray powder diffraction pattern using Cu-Kα radiation, expressed in terms of lattice spacing “d” comprising peaks at 18.4714Å, 8.3234Å, 6.0870Å, 5.0350Å, 4.7262Å, 4.6380Å, 4.5347Å, 4.3838Å, 4.2874Å, 3.9414Å and 3.6304 Å.
3. The crystalline form of claim 2 , having an X-ray powder diffraction pattern using Cu-Kα radiation, expressed in terms of lattice spacing “d” comprising peaks at 18.4714Å, 8.3234Å, 6.7220Å, 6.4396Å, 6.0870Å, 5.0350Å, 4.7262Å, 4.6380Å, 4.5347Å, 4.3838Å, 4.2874Å, 3.9414Å and 3.6304 Å.
4. The crystalline form of claim 3 , having an X-ray powder diffraction pattern using Cu-Kα radiation, expressed in terms of lattice spacing “d” comprising peaks at 18.4714Å, 8.7854Å, 8.3234Å, 6.7220Å, 6.4396Å, 6.0870Å, 5.7268Å, 5.3106Å, 5.0350Å, 4.8756Å, 4.7262Å, 4.6380Å, 4.5347Å, 4.3838Å, 4.2874Å, 4.0772Å, 3.9414Å, 3.6304Å, 3.5561Å, 3.0194Å and 2.9800Å.
5. A crystalline composition comprising the crystalline form of claim 1 , wherein the crystalline form is more than 50% by weight of the composition.
6. A process for preparing the crystalline form of claim 1 , comprising
(a) dissolving tenofovir dipivoxil fumarate in an organic solvent by heating, wherein the organic solvent is a lower alcohol or a lower ketone;
(b) adding water; and
(c) precipitating a crystalline form of tenofovir dipivoxil fumarate.
7. The process of claim 6 , wherein the step (c) is carried out under cooling.
8. The process of claim 6 , further comprising
(d) filtrating; and
(e) drying.
9. The process of claim 6 , comprising
(a) dissolving tenofovir dipivoxil fumarate in an organic solvent by heating, wherein 2 Kg to 6 Kg of the organic solvent is used per kilogram of tenofovir dipivoxil fumarate, the organic solvent is selected from one or more solvents of methanol, ethanol, propanol, isopropanol, n-butanol, isobutanol, tert-butanol, acetone and butanone, and the heating temperature is 35° C. to 70° C.;
(b) adding water, wherein 5 Kg to 15 Kg of water is added per kilogram of tenofovir dipivoxil fumarate; and
(c) precipitating a crystalline form of tenofovir dipivoxil fumarate.
10. The process of claim 9 , wherein the step (c) is carried out with cooling to a temperature of −10° C. to 5° C.
11. The process of claim 9 , further comprising
(d) filtrating; and
(e) drying under reduced pressure at a temperature range of 40° C. to 70° C.
12. A pharmaceutical composition, comprising a therapeutically effective amount of the crystalline form of claim 1 .
13. A method for ameliorating HIV and HBV infection in a mammal, comprising administrating a therapeutically effective amount of the crystalline form of claim 1 to the mammal in need thereof.
14. A crystalline composition comprising the crystalline form of claim 2 , wherein the crystalline form is more than 50% by weight of the composition.
15. A crystalline composition comprising the crystalline form of claim 3 , wherein the crystalline form is more than 50% by weight of the composition.
16. A crystalline composition comprising the crystalline form of claim 4 , wherein the crystalline form is more than 50% by weight of the composition.
17. A method for relieving symptoms caused by HIV and HBV infection in a mammal, comprising administrating a therapeutically effective amount of the crystalline form of claim 1 to the mammal in need thereof.