Oral compositions comprising a zinc compound and an anti-microbial agent
Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.
1. An oral composition comprising:
a first component comprising at least one E h -raising compound and a pharmaceutically acceptable carrier, and
a second component comprising at least one zinc compound, cetylpyridinium chloride (CPC) and a pharmaceutically acceptable carrier,
wherein the first component comprises about 0.01% by weight to about 3.0% by weight of the at least one E h -raising compound, and wherein the second component comprises about 0.01% by weight to about 2.0% by weight of zinc ion and about 0.02% by weight to about 1.0% by weight of CPC.
2. The oral composition of claim 1 , wherein the first and second components are stored separately.
3. The oral composition of claim 1 , wherein the at least one E h -raising compound is selected from the group consisting of hydrogen peroxide, a fermentable sugar, an oxyhalogen compound, a biologically-compatible oxidation-reduction buffer, and combinations thereof.
4. The oral composition of claim 1 , wherein the at least one E h -raising compound is selected from the group consisting of hydrogen peroxide and a fermentable sugar, and wherein the first composition further comprises a chlorine-containing compound.
5. The oral composition of claim 4 , wherein the chlorine-containing compound is selected from the group consisting of alkali metal chloride salts, alkaline earth metal chloride salts, and combinations thereof.
6. The oral composition of claim 1 , wherein the at least one zinc compound is selected from the group consisting of zinc chloride, zinc acetate, zinc salicylate, zinc sulfate, zinc nitrate, and combinations thereof.
7. The oral composition of claim 1 , wherein the at least one E h -raising compound is selected from the group consisting of hydrogen peroxide, sodium chlorite and a fermentable sugar; and the zinc compound is selected from the group consisting of zinc chloride and zinc acetate.
8. The oral composition of claim 1 , wherein the first component comprises about 0.01% by weight to about 3.0% by weight of the at least one E h -raising compound, and wherein the second component comprises about 0.02% by weight to about 1.0% by weight of zinc ion and about 0.02% by weight to about 0.6% by weight of CPC.
9. The oral composition of claim 5 , wherein the first component comprises about 0.5% by weight to about 2.5% by weight of the chlorine-containing compound, and wherein the second component comprises about 0.02% by weight to about 1.0% by weight of zinc ion and about 0.02% by weight to about 0.6% by weight of CPC.
10. The oral composition of claim 1 , wherein a pH of the first component ranges from about 7.0 to about 8.5, and a pH of the second component ranges from about 3.0 to about 6.0.
11. The oral composition of claim 1 , further comprising essential oils.
12. The oral composition of claim 1 , further comprising xylitol.
13. The oral composition of claim 1 , wherein the oral composition further comprises at least one additional component selected from the group consisting of a desensitizing agent, a whitening agent, an anti-microbial agent, an antibiotic, an anti-cavity agent, an anti-plaque agent, an anti-tartar agent, an agent to alleviate or reduce dry mouth, a deodorizer, a polishing agent, a detergent and a sweetener.
14. The oral composition of claim 1 , wherein the first component comprises about 0.04% by weight to about 1.2% by weight of sodium chlorite and a pH of the first component ranges from about 7.0 to about 8.5, and wherein the second component comprises about 0.04% by weight to about 0.7% by weight of zinc ion and about 0.09% by weight to about 0.2% by weight of CPC and a pH of the second component ranges from about 3.0 to about 6.0.
15. The oral composition of claim 1 , wherein the first and the second components are present separately within the composition in one or more containers, a syringe, a two-phase tablet, or chew.
16. The oral composition of claim 1 , wherein the first component is a solution and the second component is a solution; or wherein one of the components is a solution and the other component is present in an encapsulated form within the solution.
17. The oral composition of claim 1 , wherein the composition is a solid, liquid, spray, gel, foam, syrup, or powder.
18. The oral composition of claim 1 , wherein the oral composition is in a form selected from the group consisting of a dental care product, a food product, a tablet, a flash-melt formulation, a candy, a lozenge, a chewing gum, a confection, a toothpaste, a mouthrinse, a breath spray and a mint.
19. The oral composition of claim 1 comprising:
about 0.005% by weight to about 1.5% by weight of an E h -raising compound;
about 0.01% by weight to about 0.5% by weight of zinc ion;
about 0.01% by weight to about 0.3% by weight of CPC; and
at least one pharmaceutically acceptable carrier,
wherein the oral composition is prepared by mixing a first component comprising the E h -raising compound and a pharmaceutically acceptable carrier and a second component comprising a zinc compound, CPC and a pharmaceutically acceptable carrier.
20. An oral care system, comprising the oral composition of claim 1 .
21. A method for reducing oral malodor comprising delivering the oral composition of claim 1 to an oral cavity in a subject.
22. The method of claim 21 , further comprising, prior to delivering the oral composition to an oral cavity in a subject, mixing the first component and the second component.
23. The method of claim 21 , wherein the method is effective to reduce oral malodor for at least about 2 hours to about 12 hours.
24. A method for treating or alleviating a dental disease comprising delivering the oral composition of claim 1 to an oral cavity in a subject.
25. The method of claim 24 , further comprising, prior to delivering the oral composition to an oral cavity in a subject, mixing the first component and the second component.
26. The method of claim 24 , wherein the dental disease is selected from the group consisting of gingivitis, periodontitis and tooth decay.
27. A method for reducing plaque comprising delivering the oral composition of claim 1 to an oral cavity in a subject.
28. The method of claim 27 , further comprising, prior to delivering the oral composition to an oral cavity in a subject, mixing the first component and the second component.
29. A method to reduce canker sores comprising delivering the oral composition of claim 1 to an oral cavity in a subject.
30. The method of claim 29 , further comprising, prior to delivering the oral composition to an oral cavity in a subject, mixing the first component and the second component.