Methods for improving the quality of the meibum composition of meibomian glands
This invention relates to methods for improving changing the quality of the meibum composition of the meibomian glands to enhance or improve the lipid layer of the tear and increase tear breakup time by way of elevating the omega-3 index in patients suffering from symptoms of dry eye, posterior blepharitis, and/or meibomian gland dysfunction. The methods comprise administering a supplementation of omega-3 fatty acids to a patient having an inflamed meibomian gland so as to facilitate an increase in the amount of omega-3's acting as an anti-inflammatory and, respectively, decrease the amount of omega-6's (arachidonic acid) acting as an inflammatory in the composition of the meibum, thereby normalizing the lipid layer of the tear and effectively reducing the associated symptoms. In certain embodiments, the supplementation of omega-3's comprises the esterified or re-esterified triglyceride form.
1. A method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands, comprising the steps of:
administering a composition consisting of an effective amount of omega-3 fatty acids on a daily dosage basis to a mammal having inflamed or dysfunctional meibomian glands, wherein said omega-3 fatty acids includes eirosapentaenoic acid (EPA) in an amount greater than 600 mg and comprising the triglyceride form;
increasing levels of anti-inflammatory omega-3's in a composition of meibum of said treated meibomian glands; and
decreasing levels of inflammatory omega-6's in said composition of meibum.
2. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 1 , wherein said EPA comprises an amount between 1,600 mg and 2,500 mg.
3. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 1 , wherein said EPA comprises an amount between 1,600 mg and 1,800 mg.
4. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 1 , wherein said effective amount of omega-3 fatty acids includes docosahexaenoic acid (DHA) in an amount greater than 500 mg.
5. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 4 , wherein said DHA comprises an amount between 500 mg and 900 mg.
6. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 4 , wherein said effective amount of omega-3 fatty acids comprises said amount of EPA and said amount of DHA in a 3:1 ratio.
7. The method for improving the quality of the meibum concentration of inflamed or dysfunctional meibomian glands as defined in claim 1 , further comprising the step of improving tear break up time of said mammal.
8. The method for improving the quality of the meibum concentration of inflamed or dysfunctional meibomian glands as defined in claim 1 , further comprising the step of reducing tear osmolarity of said mammal.
9. The method for improving the quality of the meibum concentration of inflamed or dysfunctional meibomian glands as defined in claim 1 , further comprising the step of improving the quality of tears of said mammal.
10. A method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands, comprising the steps of:
administering a composition consisting of an effective amount of omega-3 fatty acids on a daily dosage basis to a mammal having inflamed or dysfunctional meibomian glands, wherein said omega-3 fatty acids includes eicosapentaenoic acid (EPA) in an amount greater than 600 mg and comprising the triglyceride form;
increasing levels of anti-inflammatory omega-3's in a composition of meibum of said treated meibomian glands;
decreasing levels of inflammatory omega-6's in said composition of meibum; and
improving the quality of tears of said mammal.
11. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 10 , wherein said effective amount of EPA comprises an amount between 1,600 mg and 2,500 mg.
12. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 10 , wherein said effective amount of EPA comprises an amount between 1,600 mg and 1,800 mg.
13. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined claim 10 , wherein said effective amount of omega-3 fatty acids includes docosahexaenoic acid (DHA) in an amount greater than 500 mg.
14. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 13 , wherein said effective a mount of DHA comprises an amount between 500 mg and 900 mg.
15. The method for improving the quality of the meibum concentration of inflamed or dysfunctional meibomian glands defined in claim 13 , wherein said effective amount of EPA and said effective amount of DHA is in a 3:1 ratio.
16. A method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands, comprising the steps of:
administering a composition consisting of an effective amount of omega-3 fatty acids on a daily dosage basis to a mammal having inflamed or dysfunctional meibomian glands, wherein said omega-3 fatty acids includes eicosapentaenoic acid (EPA) in an amount greater than 600 mg and comprising the triglyceride form;
increasing levels of anti-inflammatory omega-3's in a composition of meibum of said treated meibomian glands;
decreasing levels of inflammatory omega-6's in said composition of meibum; and
improving tear break up time of said mammal.
17. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 16 , wherein said effective amount of EPA comprises an amount between 1,600 mg and 2,500 mg.
18. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 16 , wherein said effective amount of omega-3 fatty acids includes docosahexaenoic acid (DHA) in an amount greater than 500 mg.
19. The method for improving the quality of the meibum concentration of inflamed or dysfunctional meibomian glands as defined in claim 18 , wherein said effective amount of EPA and said effective amount of DHA is in a 3:1 ratio.
20. A method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands, comprising the steps of:
administering a composition consisting of an effective amount of omega-3 fatty acids on a daily dosage basis to a mammal having inflamed or dysfunctional meibomian glands, wherein said omega-3 fatty acids includes eicosapentaenoic acid (EPA) in an amount greater than 600 mg and comprising the triglyceride form;
increasing levels of anti-inflammatory omega-3's in a composition of meibum of said treated meibomian glands;
decreasing levels of inflammatory omega-6's in said composition of meibum; and
reducing tear osmolarity of said mammal.
21. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 20 , wherein said effective amount of EPA comprises an amount between 1,600 mg and 2,500 mg.
22. The method for improving the quality of the meibum composition of inflamed or dysfunctional meibomian glands as defined in claim 20 , wherein said effective amount of omega-3 fatty acids includes docosahexaenoic acid (DHA) in an amount greater than 500 mg.
23. The method for improving the quality of the meibum concentration of inflamed or dysfunctional meibomian glands as defined in claim 22 , wherein said effective amount of EPA and said effective amount of DHA is in a 3:1 ratio.