Small molecule inhibitors of ebola and lassa fever viruses and methods of use
The present invention relates to compositions and methods for the treatment of infection by enveloped viruses, such as Ebola and Lassa fever viruses.
1. A compound represented by formula II:
or a pharmaceutically acceptable salt, solvate, hydrate, chemically-protected form, enantiomer or stereoisomer thereof; wherein, independently for each occurrence,
L 1 is
L 2 is
l 1 is a bond to L 1 ;
l 2 is a bond to L 2 ;
a 1 is a bond to
a 2 is a bond to
a 3 is a bond to
X is a bond,
R 3 is hydrogen or alkyl;
R 4 is hydrogen, alkyl, aralkyl, or alkylcarbonyl; and
R 5 is hydrogen, or alkyl, haloalkyl, or alkyl substituted with hydroxy, cyano, carboxy, aralkyloxy, alkyloxycarbonyl or aralkyloxycarbonyl;
provided that the compound is not
2. The compound of claim 1 , wherein
3. The compound of claim 1 , wherein
4. The compound of claim 1 , wherein
5. The compound of claim 1 , wherein
6. The compound of claim 1 , wherein
and R 4 is alkyl.
7. The compound of claim 1 , wherein
and X is
8. The compound of claim 1 , wherein
and R 3 and R 5 are hydrogen.
9. The compound of claim 1 , wherein
and X is a bond.
10. The compound of claim 1 , wherein
X is a bond; and R 4 is alkyl.
11. The compound of claim 1 , wherein L 1 is
12. The compound of claim 1 , wherein L 1 is
and X is a bond.
13. The compound of claim 1 , wherein L 2 is
14. The compound of claim 1 , wherein L 2 is
and X is —CH 2 —.