IP Library › Granted Patent US 10,800,725
Granted Patent B2
US 10,800,725 · App. 13/821,787 · Granted Oct 13, 2020

Arylpropionyl-triketone antibacterial agents

Inventors: Richard H. Ebright (New Brunswick, NJ); Juan Shen (New Brunswick, NJ)
C07C49/723C07C49/747C07C49/753C07C2601/16
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Quick Facts
Patent No.
US 10,800,725
App. No.
13/821,787
Granted
Oct 13, 2020
Kind
B2
Abstract

The invention provides a compound of formula (I): or a salt thereof, wherein R 1 -R 5 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as RNA polymerase inhibitors and antibacterial agents.

Claims (3)

1. A compound having the following structure:

or a tautomer thereof, or a pharmaceutically acceptable salt thereof.

2. A composition comprising the compound of claim 1 or a tautomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable vehicle.

Assignments (1)
CONFIRMATORY LICENSE Recorded May 21, 2013
From: RUTGERS THE STATE UNIV NEW BRUNSWICK
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030454/0836 →
Continuity (3)
Provisional Application 61381117 · Sep 9, 2010
Provisional Application 61498385 · Jun 17, 2011
Related Publication 20130289128A1 · Oct 31, 2013