IP Library Granted Patent US 8,992,971
Granted Patent B2
US 8,992,971 · App. 13/825,304 · Granted Mar 31, 2015

Non-animal soft capsule shell composition having improved disintegration and shell hardness

Inventor: Joo-Hwan Yang (Gyeonggi-do, KR)
Assignee: Suheung Capsule Co., Ltd.
A61K47/36A61K9/4816A61J3/07
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Quick Facts
Patent No.
US 8,992,971
App. No.
13/825,304
Granted
Mar 31, 2015
Kind
B2
Abstract

The present invention relates to a non-animal soft capsule shell composition having improved disintegration stability and shell hardness. More particularly, the present invention relates to a non-animal soft capsule shell composition and to a method for preparing same, in which an antioxidant and a disintegration aid are added to the non-animal soft capsule shell composition that is typically made of starch or a starch derivative, gums, a plasticizer, a buffering agent, and purified water which inhibit starch retrogradation and thus inhibit an increase in disintegration stability and capsule shell hardness, thereby improving disintegration stability and shell hardness.

Claims (14)

1. A non-animal derived soft capsule shell composition having improved disintegration and shell hardness comprising:

i) 18 to about 25 wt % of mixed starch containing hydroxypropylated tapioca starch/cross-linked potato starch/hydroxypropylated maize starch in the ratio of 1/0.1 to about 0.5/0.1 to about 0.3;

ii) 3 to about 6 wt % of iota-carrageenan as gelling agent;

iii) 5 to about 20 wt % of plasticizer;

iv) 0.01 to about 3 wt % of buffering agent;

v) 0.01 to about 2 wt % of disintegration agent at least one selected from glucoamylase, maltogenic amylase, alpha-amylase, beta-amylase, iso-amylase or pullulanase;

vi) 0.01 to about 1 wt % of antioxidant; and

vii) 45 to about 60 wt % of purified water.

2. The non-animal derived soft capsule shell composition according to claim 1 , wherein the amount of said iota-carrageenan is in the range of 3.5 to about 5.5 wt %.

3. The non-animal derived soft capsule shell composition according to claim 1 , wherein said non-animal derived soft capsule shell composition comprises 2 to about 4 wt % of iota-carrageenan and 0.5 to about 1.5 wt % of kappa-carrageenan as gelling agent; 5 to about 20 wt % of plasticizer; 0.01 to about 3 wt % of buffering agent; 0.01 to about 2 wt % of disintegration agent; 0.01 to about 1 wt % of antioxidant and 45 to about 60 wt % of purified water.

4. The non-animal derived soft capsule shell composition according to claim 3 , wherein the amount of said iota-carrageenan is in the range of 2.5 to about 3.5 wt % and the amount of said kappa-carrageenan is in the range of 0.8 to about 1.2 wt %.

5. The non-animal derived soft capsule shell composition according to claim 1 , wherein said plasticizer is at least one selected from mannitol, crystalline or non-crystalline sorbitol, sorbitan, sucrose, xylitol, erythritol, maltitol, oligo sugar, iso-malto oligo sugar, glycerin, diglycerol or triglycerol.

6. The non-animal derived soft capsule shell composition according to claim 1 , wherein said buffering agent is at least one selected from organo-metal salt, sodium phosphate dibasic or potassium phosphate dibasic.

7. The non-animal derived soft capsule shell composition according to claim 1 , wherein said antioxidant is at least one selected from rosemary extract, green tea extract, tocopherol or gallic acid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 26, 2013
From: YANG, JOO-HWAN
To: SUHEUNG CAPSULE CO., LTD.
Reel/Frame 030083/0776 →
Priority Claims (3)
KR 10-2011-0036823 · Apr 20, 2011 · national
KR 10-2012-0026919 · Mar 16, 2012 · national
KR 10-2012-0026920 · Mar 16, 2012 · national
Continuity (1)
Related Publication 20130302309A1 · Nov 14, 2013