IP Library Granted Patent US 9,532,729
Granted Patent B2
US 9,532,729 · App. 13/825,762 · Granted Jan 3, 2017

Self-assembled magnetic arrays

Inventors: Ralph Weissleder (Peabody, MA); Hakho Lee (Acton, MA); David Issadore (Boston, MA)
Assignee: The General Hospital Corporation
A61B5/055B03C1/0332B03C1/288H01F1/009H01F1/068B03C2201/18B03C2201/26G01R33/383
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Quick Facts
Patent No.
US 9,532,729
App. No.
13/825,762
Granted
Jan 3, 2017
Kind
B2
Abstract

A magnetic device includes a substrate and an array including a plurality of magnetic particles, in which a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles in the array alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle or directly adjacent magnetic particles in the array.

Claims (15)

1. A magnetic device comprising:

a substrate;

an array including a plurality of magnetic particles arranged in a single layer on the substrate, wherein a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle in the array, wherein an average maximum dimension of each particle of the plurality of magnetic particles is between about 50 nm to about 100 microns, and wherein directly adjacent particles within the array are separated by a spacing of 5 nm or less;

a fluid flow channel having a bottom surface arranged adjacent to the array, wherein the magnetic dipole moment direction of each magnetic particle in the majority of the magnetic particles is oriented orthogonal to the bottom surface of the fluid flow channel; and

a chaotic mixer arranged in the fluid flow channel, wherein a structure of the chaotic mixer is arranged and configured to create a fluid force, within a fluid flowing in the fluid channel, in a direction toward the array.

2. The magnetic device according to claim 1 , wherein the magnetic particles in the array comprise permanent magnets.

3. The magnetic device according to claim 1 , wherein the magnetic particles in the array comprise a superparamagnetic material.

4. The magnetic device according to claim 1 , wherein the magnetic particles in the array comprise one or more of NdFeB, SmCo, FePt, and iron oxide.

5. The magnetic device according to claim 1 , further comprising a suspension layer, wherein the array of magnetic particles is located in the suspension layer.

6. The magnetic device according to claim 5 , wherein the suspension layer comprises a curable polymer.

7. The magnetic device according to claim 6 , wherein the polymer comprises polyurethane, epoxy, poly(methyl methacrylate) (PMMA), or polydimethylsiloxane (PDMS).

8. The magnetic device according to claim 1 , further comprising:

a sheet coated with an adhesive that adheres to the array of magnetic particles.

9. The magnetic device according to claim 1 , wherein the plurality of magnetic particles in the array is close-packed.

10. The magnetic device according to claim 1 , further comprising a plurality of fluid flow channels arranged adjacent to the array.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 22, 2015
From: MASSACHUSETTS GENERAL HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035987/0521 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2013
From: WEISSLEDER, RALPH; LEE, HAKHO; ISSADORE, DAVID
To: THE GENERAL HOSPITAL CORPORATION
Reel/Frame 031228/0347 →
Continuity (1)
Related Publication 20130271250A1 · Oct 17, 2013