Polynucleotides encoding an actriib antibody
The disclosure provides, among other aspects, neutralizing antibodies and portions thereof that bind to ActRIIB and uses for same.
1. An isolated polynucleotide sequence encoding an anti-ActRIIB antibody or functional fragment thereof that binds to ActRIIB between amino acids 20-134 of SEQ ID NO:1, wherein said antibody or functional fragment thereof comprises a variable heavy chain encoded by the nucleic acid sequence of SEQ ID NO: 17 and a variable light chain encoded by the nucleic acid sequence of SEQ ID NO: 18.
2. A cloning or expression vector comprising the isolated polynucleotide sequence according to claim 1 .
3. An isolated host cell comprising the vector according to claim 2 .
4. A process for the production of an antibody or functional fragment thereof that binds to ActRIIB between amino acids 20-134 of SEQ ID NO:1, comprising culturing the host cell of claim 3 and isolating the antibody or functional fragment thereof.