Coated Surgical Mesh, and Corresponding Systems and Methods
Disclosed herein is a surgical mesh with a layer of dehydrated basement membrane formed thereon. Methods of making and using the mesh also are disclosed.
1 . A surgical mesh with a layer of dehydrated basement membrane formed thereon.
2 . The surgical mesh of claim 1 , wherein the basement membrane is dehydrated when in the form of a gel at room temperature.
3 . The surgical mesh of claim 1 , wherein the basement membrane is dehydrated at a temperature in the range of 1-4 Dec. C after being placed on the sensor tip when the basement membrane is in the form of a liquid.
4 . The surgical mesh of claim 1 , wherein the basement membrane is dehydrated at a temperature in the range of 10-30 Dec. C.
5 . The surgical mesh of claim 1 , wherein the basement membrane is applied in multiple layers, and the basement membrane is dehydrated after application of each layer.
6 . The surgical mesh of claim 1 , wherein the mesh also comprises layers of other extracellular matrices formed thereon.
7 . The surgical mesh of claim 1 , wherein the basement membrane contains cells and/or factors.
8 . The surgical mesh of claim 7 , wherein the cells and/or factors are crosslinked to the basement membrane with fibronectin.
9 . A kit comprising the surgical mesh of claim 1 enclosed in sterile packaging.
10 . A method comprising:
obtaining an implantable device comprising a surgical mesh,
placing basement membrane in the form of a liquid or gel on the implantable device to form at least one of a sleeve and a collar on the device, and
dehydrating the basement membrane on the implantable device.
11 . The method of claim 10 , further comprising:
inserting the sensor in a biological tissue, and
rehydrating the basement membrane after insertion.
12 . The method of claim 11 , wherein the basement membrane contains adenovirus vectors containing a VEGF gene.
13 . A method of making the implantable device of claim 1 .
14 . A method of promoting the biocompatibility of a surgical mesh with biological tissue, comprising forming an extracellular matrix coating around a surgical mesh, the coating comprising dehydrated extracellular matrix which is rehydrated after implantation, the extracellular matrix having cells and/or factors attached thereto using fibronectin.