Inhibiting transient receptor potential ion channel TRPA1
View Patent ↗This disclosure describes a novel compounds and pharmaceutical compositions for inhibiting the TRPA1 ion channel and/or medical conditions related to TRPA1, such as pain.
1. A method for treating or ameliorating pain, comprising intravenously administering to an animal or human an effective amount of a pharmaceutical composition comprising a compound of Formula (Ia), or a pharmaceutically acceptable salt thereof:
2. The method of claim 1 , wherein the compound of Formula (Ia) is in the form of a hydrochloride salt.
3. The method of claim 1 , wherein the pain is acute pain.
4. The method of claim 1 , wherein the pain is chronic pain.
5. The method of claim 1 , wherein the pain is post-surgical pain.
6. The method of claim 1 , wherein the pain is inflammatory pain.
7. A compound of Formula (Ia), or a pharmaceutically acceptable salt of the compound of Formula (Ia):
8. The compound of claim 7 , comprising the hydrochloride salt of the compound of Formula (Ia).
9. A compound of Formula (I), or a pharmaceutically acceptable salt thereof:
10. A compound according to claim 9 in the form of its hydrochloride salt.
11. A method for treating or ameliorating pain, comprising orally administering to an animal or human an effective amount of a pharmaceutical composition comprising a compound of Formula (Ia), or a pharmaceutically acceptable salt thereof: