Disaccharide synthetic lipid compounds and uses thereof
Essentially pure compounds of the formulas (I) to (XX) are provided. Compositions and methods for enhancing or stimulating an immune response are also provided. The compounds, provided are advantageous in that the compounds are essentially pure and free from contaminants encountered when such compounds are purified from natural sources.
1. An essentially pure compound having the structure:
2. The essentially pure compound of claim 1 , wherein the compounds is at least 95% pure with respect to the synthetic disaccharide lipid compounds as measured on a weight basis.
3. The essentially pure compound of claim 1 , wherein the compounds is at least 99% pure with respect to the synthetic disaccharide lipid compounds as measured on a weight basis.
4. A pharmaceutical composition comprising:
a. a pharmaceutically acceptable carrier;
b. an optional antigen; and
c. an essentially pure compound having the structure
or a pharmaceutically acceptable salt thereof.
5. The pharmaceutical composition of claim 4 , wherein the compounds is at least 95% pure with respect to the synthetic disaccharide lipid compounds as measured on a weight basis.
6. The pharmaceutical composition of claim 4 , wherein the compounds is at least 99% pure with respect to the synthetic disaccharide lipid compounds as measured on a weight basis.
7. The pharmaceutical composition of claim 4 , wherein the composition comprises an antigen.
8. The pharmaceutical composition of claim 4 , wherein the composition further comprises a second adjuvant.
9. The pharmaceutical composition of claim 8 , wherein the second adjuvant is a mono-phosphorylated hexaacyl disaccharide.
10. The pharmaceutical composition of claim 4 , wherein the composition is a vaccine composition.
11. The pharmaceutical composition of claim 4 , wherein the composition is useful in stimulating or enhancing an immune response in a subject.
12. The pharmaceutical composition of claim 4 , wherein the pharmaceutically acceptable carrier is a liposome.