IP Library Granted Patent US 9,078,884
Granted Patent B2
US 9,078,884 · App. 13/842,972 · Granted Jul 14, 2015

Bio-material composition and method for spinal fusion

Inventor: Thomas Joseph Lally (Oak Brook, IL)
A61K33/42A61K33/08A61L27/12A61L27/54A61L2300/414A61L2430/38
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Quick Facts
Patent No.
US 9,078,884
App. No.
13/842,972
Granted
Jul 14, 2015
Kind
B2
Abstract

The present invention relates to a material and method for providing spinal fusion. One preferred method comprises: accessing the intervertebral space defined between adjacent vertebrae; mixing magnesia, potassium biphosphate, and a calcium phosphate with an aqueous solution forming an activated spinal fusion slurry (ASFS); applying an effective amount of the ASFS to the intervertebral space between adjacent vertebrae; allowing the ASFS to set forming a bonded vertebrae structure; permitting bone growth into the bonded vertebrae structure providing fusion of the two adjacent vertebrae.

Claims (35)

1. A method for fusing two adjacent vertebrae comprising:

accessing the intervertebral space defined between adjacent vertebrae;

mixing magnesia, potassium biphosphate, and a calcium phosphate with an aqueous solution forming an activated spinal fusion slurry (ASFS);

applying an effective amount of the ASFS to the intervertebral space between adjacent vertebrae;

allowing the ASFS to set forming a bonded vertebrae structure;

permitting bone growth into the bonded vertebrae structure providing fusion of the two adjacent vertebrae; wherein the ASFS promotes spinal fusion without the need for the fixation material BMP-2.

2. The method of claim 1 , wherein the ASFS is applied to the transverse process.

3. The method of claim 1 , wherein the ASFS has putty like consistency.

4. The method of claim 1 , wherein the ASFS promotes spinal fusion without the need of any additional fixation devices and/or materials.

5. The method of claim 1 , wherein the ASFS promotes spinal fusion without the need of the fixation material MPDH.

6. The method of claim 1 , wherein the ASFS provides spinal fusion without the need for additional physical fixation devices.

7. The method of claim 1 , wherein the applied ASFS is absorbed and replaced by bone over time.

8. The method of claim 1 , wherein the ASFS initially provides structural strength and over time is replaced with new bone growth that fuses the vertebrae.

9. A method of providing spinal fusion comprising:

supplying a dry magnesium containing mixture comprising: magnesia, potassium biphosphate, and a tertiary calcium phosphate, wherein the weight percent ratio of potassium biphosphate to magnesia is between about 3:1 and 1:1;

mixing the dry magnesium containing mixture with an aqueous solution forming an activated spinal fusion slurry (ASFS);

applying an effective amount of the ASFS to a site between two vertebrae;

allowing the ASFS to set, forming a bonded vertebrae structure;

permitting bone growth into the bonded vertebrae structure providing fusion of the two adjacent vertebrae; wherein the ASFS promotes spinal fusion without the need for the fixation material BMP-2.

10. The method of claim 9 , wherein the site between two vertebrae is the transverse process.

11. The method of claim 9 , wherein the ASFS initially provides structural strength and over time is replaced with new bone growth that fuses the vertebrae.

12. A method to fuse vertebrae comprising:

supplying a dry magnesium containing mixture comprising: magnesia, potassium phosphate, and a tertiary calcium phosphate, wherein the weight percent ratio of potassium phosphate to magnesia is between about 3:1 and 1:1;

mixing the dry magnesium containing mixture with an aqueous solution forming an activated spinal fusion slurry (ASFS);

applying an effective amount of the ASFS to a site between two vertebrae;

allowing the ASFS to set, forming a bonded vertebrae structure;

permitting bone growth into the bonded vertebrae structure providing fusion of the two adjacent vertebrae; wherein the ASFS promotes spinal fusion without the need for the fixation material BMP-2.

13. The method of claim 12 , wherein the site of application is the transverse process between two or more vertebrae.

14. The method of claim 12 , wherein the dry mixture further comprises: a sugar compound.

15. The method of claim 12 , where the dry mixture further comprises:

mono-sodium phosphate.

16. The method of claim 14 , wherein the sugar compound selected from the group consisting of: sugars, sugar derivatives, sugar replacements and combinations thereof.

17. The method of claim 14 , wherein the sugar compound is selected from a group consisting of: sugars, sugar alcohols, sugar acids, amino sugars, sugar polymers glycosaminoglycans, glycolipds, sugar substitutes and combinations thereof.

18. The method of claim 14 , wherein the sugar compound comprises sucrose.

19. The method of claim 12 , wherein the tertiary calcium phosphate is Ca 10 (PO 4 ) 6 (OH) 2 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2016
From: LALLY, THOMAS
To: BONE SOLUTIONS, INC.
Reel/Frame 038330/0778 →
Continuity (7)
Continuation In Part 13244533 · Sep 25, 2011
Continuation In Part 11813365
Continuation In Part 11575590
Provisional Application 61686448 · Apr 5, 2012
Provisional Application 60643312 · Jan 12, 2005
Provisional Application 60611840 · Sep 21, 2004
Related Publication 20130216629A1 · Aug 22, 2013