1,3,4-oxadiazole and 1,3,4-thiadiazole beta-lactamase inhibitors
View Patent ↗β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound of claim 1 and at least 1 β-lactam antibiotic.
3. The pharmaceutical composition of claim 2 wherein the β-lactam antibiotic is a cephalosporin.
4. The pharmaceutical composition of claim 2 wherein the β-lactam antibiotic is a carbapenem.
5. The pharmaceutical composition of claim 2 wherein the β-lactam antibiotic is a monobactam.