Polynuclear microcapsules
View Patent ↗A process is disclosed for preparing polynuclear microcapsules by polymerizing an alkoxysilane at the oil/water interface of a multiple phase emulsion to form a suspension of polynuclear microcapsules. Also disclosed are polynuclear microcapsules optionally comprising a hydrophilic active and uses thereof.
1. A polynuclear microcapsule which comprises an outer-capsule
wherein the outer-capsule comprises an outer-shell and a plurality of innercapsules,
wherein each of the inner-capsules comprises an inner-shell and an aqueous phase core,
wherein the outer-shell and the inner-shell further comprise a silica or an organofunctional silica.
2. The polynuclear microcapsule of claim 1 wherein the silica or organofunctional silica comprises a reaction product from the polymerization of an alkoxysilane or a mixture of alkoxysilanes at the oil/water interfaces of a multiple phase emulsion.
3. The polynuclear microcapsule of claim 1 wherein the aqueous phase core comprises a hydrophilic active.
4. The polynuclear microcapsule of claim 2 wherein the aqueous phase core comprises a hydrophilic active.
5. The polynuclear microcapsule of claim 2 wherein the alkoxysilane is tetraethoxysilane.
6. The polynuclear microcapsule of claim 3 wherein the weight percent of the hydrophilic active is between 0.01 percent and 90 percent.
7. The polynuclear microcapsule of claim 6 , wherein the hydrophilic active comprises a drug, a vitamin, a sunscreen agent, a colorant, a metaloxide, or a biologic.
8. The polynuclear microcapsule of claim 7 wherein the biologic is an enzyme.
9. The polynuclear microcapsule of claim 3 wherein the polynuclear microcapsule has an average volume particle size of between 0.5 micrometers and 1000 micrometers.
10. The polynuclear microcapsule of claim 3 wherein the average volume particle size is between 0.5 micrometers and 20 micrometers.
11. The polynuclear microcapsule of claim 3 wherein the average volume particle size is between 10 and 500 micrometers.
12. A composition comprising a polynuclear microcapsule of claim 1 and at least one pharmaceutically-acceptable carrier, adjuvant or diluent.