Compositions and methods for treating
Compositions containing about 0.6% to about 20% of tea tree oil are described. Some compositions are in the form of solutions, suspensions, spray, lotions, gels, pastes, medicated sticks, balms, cleansers (including shampoos and soaps), creams, or ointments. Also described are compositions and methods for use in treating ocular Demodex infestations and related conditions using such compositions.
1. A cleaning device comprising a solution consisting essentially or:
a. about 1% up to, but not including, 20% w/w of terpinen-4-ol as an agent; and
b. at least one ophthalmically acceptable excipient,
wherein the solution does not include tea tree oil.
2. The cleaning device of claim 1 , wherein the solution further comprises one or more pharmaceutically acceptable ointment bases.
3. The cleaning device of claim 1 , wherein the solution further comprises one or more mucoadhesive polymers.
4. The cleaning device of claim 1 , wherein the dispenser is wetted with the solution.
5. The cleaning device of claim 1 , wherein the dispenser is a cotton applicator.
6. A method of cleaning the skin of an individual, comprising contacting the skin of the individual with the cleaning device of claim 1 .
7. The method of claim 6 , wherein contacting the skin of the individual with the cleaning device comprises scrubbing the skin with the cleaning device.
8. The method of claim 6 , wherein contacting the skin of the individual with the cleaning device comprises washing the skin with the cleaning device.
9. The method of claim 6 , wherein the skin comprises a face, eye, eyelid, eyelid margin, eyelash, eyelash roots or a combination thereof.
10. The method of claim 6 , comprising contacting the skin of the individual with the cleaning device for at least 4 weeks.
11. The method of claim 6 , comprising contacting the skin of the individual with the cleaning device daily.
12. The method of claim 6 , comprising contacting the skin of the individual with the cleaning device twice daily.
13. The method of claim 6 , wherein the dispenser is wetted with the solution.
14. The method of claim 6 , wherein the dispenser is a cotton applicator.
15. The method of claim 6 , wherein said cleaning comprises treating an ocular Demodex infestation or Demodex -induced blepharitis in the individual.
16. The method of claim 6 , wherein the individual is refractory to an anti-inflammatory, conventionally anti-microbial antibiotic, or an anti-allergy therapy for ocular Demodex infestation or Demodex -induced blepharitis.