Methods of treating emesis
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK 1 ) receptor. The compounds have the general formula (I):
1. A method of treating emesis in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of the following compound:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein said emesis comprises chemotherapy-induced nausea and vomiting, radiotherapy-induced nausea and vomiting, or post-operative nausea and vomiting.
3. The method of claim 1 , wherein said emesis is induced by moderately emetogenic chemotherapy.
4. The method of claim 1 , wherein said emesis is induced by highly emetogenic chemotherapy.
5. The method of claim 1 , wherein said emesis is acute and delayed emesis induced by moderately or highly emetogenic chemotherapy.
6. The method of claim 1 , wherein said compound is administered via injection.
7. The method of claim 1 , wherein said compound is administered at a dosage of from 10 to 200 mg.
8. The method of claim 1 , further comprising administering palonosetron or a pharmaceutically acceptable salt thereof.
9. The method of claim 1 , further comprising administering palonosetron or a pharmaceutically acceptable salt thereof and dexamethasone.
10. A method of treating emesis in a patient in need thereof, comprising administering to said patient via injection a therapeutically effective amount of the following compound:
or a pharmaceutically acceptable salt thereof.
11. The method of claim 10 , wherein said emesis comprises chemotherapy-induced nausea and vomiting.
12. The method of claim 10 , wherein said emesis is acute and delayed emesis induced by moderately or highly emetogenic chemotherapy.
13. The method of claim 10 , wherein said compound is administered via injection at a dosage of from 10 to 200 mg.
14. A method of treating emesis in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of the following compound:
in combination with palonosetron or a pharmaceutically acceptable salt thereof and dexamethasone.
15. The method of claim 14 , wherein said emesis comprises chemotherapy-induced nausea and vomiting.
16. The method of claim 14 , wherein said compound is administered via injection.
17. The method of claim 14 , wherein said compound is administered via injection at a dosage of from 10 to 200 mg.
18. A method of treating emesis in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of the following compound:
or a pharmaceutically acceptable salt thereof.
19. The method of claim 18 , wherein said compound is administered via injection.
20. The method of claim 18 , wherein said compound is administered at a dosage of from 10 to 200 mg.
21. The method of claim 18 , further comprising administering palonosetron or a pharmaceutically acceptable salt thereof.