Pneumococcal Serotype 6D
Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6D, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→4) ribitol (5→phosphate. This new serotype may be included in pneumococcal vaccines.
1. An isolated or purified antigen binding molecule that binds to a polysaccharide having the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→4) ribitol (5→phosphate}; wherein the antigen binding molecule is an intact antibody, a Fab, Fab′, F(ab′) 2 or Fv fragment thereof, a CDR portion of an antibody, or a peptide or derivative of an antibody, that binds said polysaccharide repeating unit.
2. An immunoassay kit comprising the antigen binding molecule of claim 1 , wherein the immunoassay differentiates for a capsular polysaccharide having the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→4) ribitol (5→phosphate}.
3. The antigen binding molecule of claim 1 , wherein the molecule is an antibody.
4. A composition comprising at least one antigen binding molecule that binds to a polysaccharide having the repeating unit {→2) glucose 1 (1→3) glucose 2 (1→3) rhamnose (1→4) ribitol (5→phosphate}; wherein the antigen binding molecule is an intact antibody, a Fab, Fab′, F(ab′) 2 or Fv fragment thereof, a CDR portion of an antibody, or a peptide or derivative of an antibody, that binds said polysaccharide repeating unit.
5. The composition of claim 4 , wherein the composition comprises monoclonal or polyclonal antibodies.
6. An immunoassay kit comprising the composition of claim 4 .