Antineoplastic combinations with mTOR inhibitor, trastuzumab and/or HKI-272
A combination of temsirolimus and trastuzumab in the treatment of cancer is provided. A combination of temsirolimus and HKI-272 is provided. A combination of a trastuzumab and a HKI-272 is also provided. Regimens and kits for treatment of metastatic breast cancer, containing trastuzumab, temsirolimus and/or HKI-272, optionally in combination with other anti-neoplastic agents, or immune modulators are described.
1. A method of treating a HER2+ neoplasm in a patient in need thereof, consisting of administering to the patient:
i) temsirolimus (CCI-779) or a prodrug or pharmaceutically acceptable salt thereof in combination with one or more pharmaceutically acceptable carriers; and
ii) 0.1 to 300 mg of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or a pharmaceutically acceptable salt thereof, in combination with one or more pharmaceutically acceptable carriers.
2. The method of claim 1 , wherein the temsirolimus (CCI-779) and (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, are administered in subtherapeutically effective amounts.
3. The method of claim 1 , wherein the neoplasm is selected from the group consisting of: lung cancer, including bronchioalveolar carcinoma and non small cell lung cancer; breast cancer; myeloma; prostate cancer; head and neck cancer; transitional cell carcinoma; and small cell and large cell neuroendocrine carcinoma of the uterine cervix.
4. The method of claim 3 , wherein the breast cancer is metastatic breast cancer.
5. The method of claim 1 , wherein the temsirolimus (CCI-779) and (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, are administered simultaneously, separately, sequentially, or in a staggered regimen to the patient.
6. The method of claim 1 , wherein the temsirolimus (CCI-779) and (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, are administered to the patient in a formulation suitable for one or more of the following administration routes: oral, as an aerosol, parenteral, intraperitoneal, transdermal, or as a suppository.
7. The method of claim 1 , wherein the temsirolimus (CCI-779) and (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, are administered to the patient using the same route of administration or using different routes of administration.
8. The method of claim 1 , wherein the temsirolimus (CCI-779) and (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, are contained in a pharmaceutical pack or kit.
9. The method of claim 1 , wherein the temsirolimus (CCI-779) is administered orally or intravenously.
10. The method of claim 9 , wherein an amount in the range of between 10 mg to 250 mg of the temsirolimus (CCI-779) is administered orally to the patient per week.
11. The method of claim 9 , wherein an amount in the range of between 5 mg to 175 mg of the temsirolimus (CCI-779) is administered intravenously to the patient per week.
12. The method of claim 11 , wherein the (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, is administered orally.
13. The method of claim 12 , wherein the (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, is administered daily.
14. The method of claim 13 , wherein an amount of 80 mg, 160 mg, or 240 mg of the (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, or pharmaceutically acceptable salt thereof, is administered orally.