IP Library Granted Patent US 10,136,835
Granted Patent B1
US 10,136,835 · App. 13/875,973 · Granted Nov 27, 2018

Determining a presence of an object

Inventors: Michael R. Bailey (Seattle, WA); Wei Lu (Seattle, WA); Oleg A. Sapozhnikov (Seattle, WA); Bryan Cunitz (Seatte, WA)
Assignee: University of Washington through its Center for Commercialization
A61B5/06A61B8/085A61B8/0833A61B8/488
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Quick Facts
Patent No.
US 10,136,835
App. No.
13/875,973
Granted
Nov 27, 2018
Kind
B1
Abstract

Methods, computing devices, and computer-readable medium are described herein related to producing detection signals configured to induce an excited state of an object. A computing device may receive reflection signals, where the reflection signals correspond to at least one detection signals reflected from the object. Based on the received reflection signals, a presence of the object in the excited state may be determined. Further, an output device may provide an indication of the presence of the object in the excited state.

Claims (36)

1. A method of detecting a kidney stone within a medium, comprising:

inducing an excited state of the kidney stone by transmitting one or more first ultrasound pulses into the medium that surrounds the kidney stone, wherein the excited state is characterized by varying a size or a shape of a bubble attached to the kidney stone, and wherein the excited state of the kidney stone has different ultrasound reflection characteristics when compared to the kidney stone in a non-excited state;

transmitting one or more second ultrasound pulses into the medium towards the kidney stone in the excited state, wherein the second ultrasound pulses have a lower amplitude than the first ultrasound pulses;

detecting one or more reflections of the one or more second ultrasound pulses off of the kidney stone in the excited state; and

determining that the kidney stone is in the medium based on detecting the one or more reflections.

2. The method of claim 1 , wherein the kidney stone is within a living body, and wherein the kidney stone comprises a calcification or a concretion.

3. The method of claim 1 , wherein determining that the kidney stone is in the medium comprises detecting a Doppler shift in the one or more reflections.

4. The method of claim 1 , wherein causing the user interface to provide the indication comprises causing the user interface to provide an image of the kidney stone or to provide a visual or audio indication that the kidney stone is within the medium.

5. The method of claim 1 , wherein at least one of the one or more second ultrasound pulses has a burst of about 5 microseconds.

6. The method of claim 1 , wherein the one or more second ultrasound pulses have a pulse repetition period of about 160 microseconds.

7. The method of claim 1 , wherein the one or more second ultrasound pulses have a pulse repetition period of about 333 microseconds.

8. The method of claim 1 , wherein the one or more first ultrasound pulses induce the excited state of the kidney stone by causing the bubble attached to the kidney stone to increase in size.

9. The method of claim 1 , wherein the one or more second ultrasound pulses include an ultrasound wave oscillating at a frequency that is greater than 2 MHz and less than 8 MHz.

10. The method of claim 1 , wherein the one or more second ultrasound pulses have a pulse repetition frequency of greater than 1 kHz and less than 5 kHz.

11. A device comprising:

a processor;

an ultrasound probe;

a user interface; and

a non-transitory computer-readable medium storing program instructions that, when executed by the processor, cause the device to perform functions comprising:

inducing an excited state of a kidney stone by transmitting, via the ultrasound probe, one or more first ultrasound pulses into a medium that surrounds the kidney stone, wherein the excited states is characterized by varying a size or a shape of a bubble attached to the kidney stone, and wherein the excited state of the kidney stone has different ultrasound characteristics when compared to the kidney stone in a non-excited state;

transmitting, via the ultrasound probe, one or more second ultrasound pulses into the medium towards the kidney stone in the excited state, wherein the second ultrasound pulses have a lower amplitude than the first ultrasound pulses;

detecting one or more reflections of the one or more second ultrasound pulses off of the kidney stone in the excited state;

determining that the kidney stone is in the medium based on detecting the one or more reflections; and

causing the user interface to provide an indication that the kidney stone is in the medium.

12. The device of claim 11 , wherein determining that the kidney stone is in the medium comprises detecting a Doppler shift in the one or more reflections.

13. The device of claim 11 , wherein the one or more second ultrasound pulses include an ultrasound wave oscillating at a frequency within a range of 2 MHz to 8 MHz.

14. The device of claim 11 , wherein the one or more second ultrasound pulses have a pulse repetition frequency that is within a range of 1 kHz to 5 kHz.

15. A non-transitory computer-readable medium storing program instructions that, when executed by a device, cause the device to perform functions comprising:

inducing an excited state of a kidney stone by transmitting, via an ultrasound probe, one or more first ultrasound pulses into a medium that surrounds the kidney stone, wherein the excited states is characterized by varying a size or a shape of a bubble attached to the kidney stone, and wherein the excited state of the kidney stone has different ultrasound characteristics when compared to the kidney stone in a non-excited state;

transmitting, via the ultrasound probe, one or more second ultrasound pulses into the medium towards the kidney stone in the excited state, wherein the second ultrasound pulses have a lower amplitude than the first ultrasound pulses;

detecting one or more reflections of the one or more second ultrasound pulses off of the kidney stone in the excited state;

determining that the kidney stone is in the medium based on detecting the one or more reflections; and

causing the user interface to provide an indication that the kidney stone is in the medium.

16. The non-transitory computer-readable medium of claim 15 , wherein determining that the kidney stone is in the medium comprises detecting a Doppler shift in the one or more reflections.

17. The non-transitory computer-readable medium of claim 15 , wherein the one or more second ultrasound pulses include an ultrasound wave oscillating at a frequency within a range of 2 MHz to 8 MHz.

18. The method of claim 15 , wherein the one or more second ultrasound pulses have a pulse repetition frequency that is within a range of 1 kHz to 5 kHz.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 9, 2016
From: UNIVERSITY OF WASHINGTON
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 038928/0983 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 13, 2013
From: BAILEY, MICHAEL R.; LU, WEI; SAPOZHNIKOV, OLEG A.; CUNITZ, BRYAN
To: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
Reel/Frame 031000/0646 →
Continuity (3)
Provisional Application 61641794 · May 2, 2012
Provisional Application 61642367 · May 3, 2012
Provisional Application 61711684 · Oct 9, 2012