Quinazoline derivatives, compositions, and uses related thereto
The invention relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the invention relates to inhibitors of NADPH-oxidase.
1. A pharmaceutical formulation comprising 6-chloro-3-(3-(dimethylamino)propyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one or salt thereof and a pharmaceutically acceptable carrier.
2. The pharmaceutical formulation of claim 1 in the form of a tablet, soft or hard gelatin or non-gelatin capsule, or caplet.
3. The pharmaceutical formulation of claim 1 wherein the pharmaceutically acceptable carrier is selected from dicalcium phosphate dihydrate, calcium sulfate, sucrose, glucose, dextrose, lactose, sorbitol, dextrose, cellulose, starch, gelatin, silicone dioxide, titanium oxide, magnesium aluminum silicate, magnesium stearate, calcium stearate, stearic acid, glycerol behenate, polyethylene glycol, talc, mineral oil, and an acrylic polymer.
4. The pharmaceutical formulation of claim 1 wherein the pharmaceutically acceptable carrier is a lubricant, surfactant, or enteric coating.