COSMETIC SKIN CARE COMPOSITIONS
The invention relates to a composition formulated for topical application for the prevention, mitigation or abrogation of skin aging or skin imperfections in a subject. The composition comprises an insoluble copper oxide as a primary active ingredient therein, wherein said insoluble copper oxide is present at a concentration of between about 0.15%-about 0.75% w/w, the insoluble copper oxide is present as particles ranging in a size of from between about 0.5 to about 10 microns or a combination thereof.
1 . A composition for the prevention, mitigation or abrogation of skin aging or skin imperfections in a subject, said composition being formulated for topical application and comprising an insoluble copper oxide as a primary active ingredient therein, wherein said insoluble copper oxide is present at a concentration of between about 0.15%-about 0.75% w/w.
2 . The composition of claim 1 , wherein said insoluble copper oxide is present at a concentration of between about 0.15%.
3 . (canceled)
4 . The composition of claim 1 , wherein said insoluble copper oxide is present at a concentration of between about 0.20%-about 0.25% w/w.
5 . The composition of claim 1 , wherein said copper oxide is cupric oxide.
6 . The composition of claim 1 , wherein said copper oxide is cuprous oxide.
7 . The composition of claim 1 , wherein said composition is a suspension comprising copper oxide particles of less than 10 microns in size.
8 . The composition of claim 1 or claim 7 , wherein said copper oxide is encapsulated.
9 . The composition of claim 8 , wherein said copper oxide is encapsulated within a shell comprising an acrylic, cellulose or a combination thereof.
10 . The composition of claim 1 , wherein said composition is a powder, a cream, a liquid, a spray, a gel, a foam, an ointment, an oil or a mask.
11 . The composition of claim 1 , further comprising a skin therapeutic agent, which skin therapeutic agent is synergistic in effect with that of the insoluble copper oxide.
12 . The composition of claim 11 , wherein said skin therapeutic agent comprises lipoxygenase inhibitors, bradykinin inhibitors, prostaglandins and their derivatives, prostaglandin receptor agonists or antagonists, nonprostanoic prostaglandin analogues, cyclosporins and their analogues, antimicrobials, anti-inflammatories, retinoids, oestradiol, protein kinase C activators, 2 5 glycosidase inhibitors, glycosaminoglycanase inhibitors, proteoglycanase inhibitors, estrogen agonists and antagonists, pseudopterins, vitamins, retinoic acid, antipruritic agents, anti-androgen agents, steroidal or non-steroidal inhibitors of 5-reductases, or mixtures thereof.
13 . A method for the prevention, mitigation or abrogation of skin aging or skin imperfections in a subject, said method comprising topically contacting affected skin in a subject with a composition comprising an insoluble copper oxide as a primary active ingredient therein, wherein said insoluble copper oxide is present at a concentration of between about 0.15%-about 0.75% w/w in said composition.
14 - 15 . (canceled)
16 . The method of claim 13 , wherein said composition is a suspension comprising copper oxide particles of between about 0.5 to about 10 microns in size.
17 - 18 . (canceled)
19 . The method of claim 13 , further comprising the step of contacting said affected skin with a second skin therapeutic agent, which second skin therapeutic agent is synergistic in effect with that of the insoluble copper oxide.
20 . (canceled)
21 . A composition for the prevention, mitigation or abrogation of skin aging or skin imperfections in a subject, said composition being formulated for topical application and comprising an insoluble copper oxide as a primary active ingredient therein, wherein said insoluble copper oxide is present as particles ranging in a size of from between about 0.5 to about 10 microns.
22 . The composition of claim 21 , wherein said copper oxide is cupric oxide.
23 . The composition of claim 21 , wherein said copper oxide is cuprous oxide.
24 . The composition of claim 21 , wherein said composition is a suspension comprising copper oxide particles of between about 0.5 to about 10 microns in size.
25 . The composition of claim 21 , wherein said composition is a powder, a cream, a liquid, a spray, a gel, a foam, an ointment, an oil or a mask.
26 - 28 . (canceled)
29 . A method for the prevention, mitigation or abrogation of skin aging or skin imperfections in a subject, said method comprising topically contacting affected skin in a subject with a composition comprising an insoluble copper oxide as a primary active ingredient therein, wherein said insoluble copper oxide is present as particles ranging in a size of from between about 0.5 to about 10 microns.
30 - 36 . (canceled)