IP Library › Granted Patent US 9,572,894
Granted Patent B2
US 9,572,894 · App. 13/878,561 · Granted Feb 21, 2017

Biodegradable particulate formulations

Inventors: Aliasger K. Salem (Iowa City, IA); Sean M. Geary (Iowa City, IA); George J. Weiner (Iowa City, IA); Caitlin Lemke (Iowa City, IA); Yogita Krishnamachari (Iowa City, IA)
Assignee: The University of Iowa Research Foundation
A61K47/48876A61K9/1647A61K31/704A61K39/0011A61K39/39A61K47/48092A61K2039/55511A61K2039/55555A61K2039/55561
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Quick Facts
Patent No.
US 9,572,894
App. No.
13/878,561
Granted
Feb 21, 2017
Kind
B2
Abstract

The present invention provides three-component compositions comprising microparticles, a tumor antigen, a first immune adjuvant, and a second immune adjuvant. Also provided are chemo-immunotherapeutic compositions comprising microparticles, a chemotherapeutic agent, and an immune adjuvant.

Claims (5)

1. A chemo-immunotherapeutic composition comprising: microparticles comprising a chemically modified surface having a net positive charge; a chemotherapeutic agent; and an immune adjuvant comprising an oligonucleotide, wherein the immune adjuvant is adsorbed on the chemically modified surface of the microparticles.

2. The composition of claim 1 , wherein the microparticles comprise a polymeric material.

3. The composition of claim 2 , wherein the polymeric material is PLGA.

4. The composition of claim 1 , wherein the chemotherapeutic agent is doxorubicin, and the immune adjuvant is CpG.

5. The composition of claim 1 , wherein the chemically modified surface of the microparticles comprises a polyamidoamine-modified surface.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2014
From: SALEM, ALIASGER K.; GEARY, SEAN M.; WEINER, GEORGE J.; LEMKE, CAITLIN; KRISHNAMACHARI, YOGITA
To: THE UNIVERSITY OF IOWA RESEARCH FOUNDATION
Reel/Frame 032923/0153 →
CONFIRMATORY LICENSE Recorded Apr 18, 2013
From: UNIVERSITY OF IOWA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030242/0223 →
Continuity (3)
Provisional Application 61394262 · Oct 18, 2010
Provisional Application 61394254 · Oct 18, 2010
Related Publication 20140127253A1 · May 8, 2014