Polyvalent chimeric OspC vaccinogen and diagnostic antigen
A chimeric polyvalent recombinant protein for use as a vaccine and diagnostic for Lyme disease is provided. The chimeric protein comprises epitopes of the loop 5 region and/or the alpha helix 5 region of outer surface protein C (OspC) types. The OspC types may be associated with mammalian Borrelia infections.
1. An isolated protein comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO:263.
2. The isolated protein of claim 1 , wherein said isolated protein comprises an amino acid sequence having at least 96% sequence identity to SEQ ID NO:263.
3. The isolated protein of claim 1 , wherein said isolated protein comprises an amino acid sequence having at least 97% sequence identity to SEQ ID NO:263.
4. The isolated protein of claim 1 , wherein said isolated protein comprises an amino acid sequence having at least 97% sequence identity to SEQ ID NO:263.
5. The isolated protein of claim 1 , wherein said isolated protein comprises an amino acid sequence having at least 98% sequence identity to SEQ ID NO:263.
6. The isolated protein of claim 1 , wherein said isolated protein comprises an amino acid sequence having at least 99% sequence identity to SEQ ID NO:263.