Compositions and methods for the treatment of traumatic brain injury
View Patent ↗Compositions and methods for the inhibition and/or prevention of traumatic brain injury and the symptoms associated with it are provided.
1. A method for reducing in a subject the pathology associated with traumatic injury to the brain, wherein said subject has sustained a traumatic brain injury, said method comprising administering to the subject at least one polymer and at least one pharmaceutically acceptable carrier,
wherein said polymer comprises at least one anti-inflammatory agent conjugated to the polymer,
wherein said polymer is a N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer having the structure:
wherein m and n are independently from about 1 to about 1000, wherein R is a linker, and wherein said linker is an alkyl having one to about 15 carbons or a peptide having 1 to about 10 amino acids.
2. The method of claim 1 , wherein said composition is administered to the subject within one day of the traumatic brain injury.
3. The method of claim 2 , wherein said composition is administered to the subject within about 6 hours of the traumatic brain injury.
4. The method of claim 1 , wherein said polymer further comprises at least one imaging agent.
5. The method of claim 1 , wherein said composition is administered intravenously, intraperitoneally, or intramuscularly.
6. The method of claim 1 , wherein said HPMA copolymer is
7. The method of claim 1 further comprising the administration of at least one additional anti-inflammatory agent.
8. The method of claim 1 , wherein said composition is administered intravenously.