Anti-staphylococcal celecoxib derivatives
A method of treating infection by Staphylococcus in a subject by administering a pharmaceutical composition including a celecoxib derivative of formula I or a pharmaceutically acceptable salt thereof is described. The preparation of numerous celecoxib derivatives for testing as potential anti-staphylococcal agents is also described.
1. A method of treating infection by Staphylococcus in a subject, comprising administering to the subject a pharmaceutical composition including a compound of formula I or a pharmaceutically acceptable salt thereof:
wherein R 1 is selected from carboxamide, sulfonamide, amino, aminosulfonamide, and acylamido groups, and R 2 is selected from aryl, aralkyl, fused aryl groups, and fused heteroaryl groups.
2. The method of claim 1 , wherein R 1 is carboxamide and R 2 is:
3. The method of claim 2 , wherein the compound of formula I has the structure:
4. The method of claim 1 , wherein R 1 is sulfonamide and R 2 is selected from the group consisting of:
5. The method of claim 1 , wherein R 1 is acylamido and R 2 is selected from the group consisting of:
6. The method of claim 5 , wherein the acylamido is an amine substituted acylamido having the structure —NH—CO—(CH 2 ) x —NH 2 , wherein x is an integer from 1-4.
7. The method of claim 1 , wherein R 1 is aminosulfonamide, and R 2 is a phenyl, biphenyl, naphthyl, or anthracenyl group.
8. The method of claim 7 , wherein the compound of formula I has the structure
9. The method of claim 1 , wherein the Staphylococcus is methicillin-resistant.
10. The method of claim 1 , wherein the Staphylococcus is Staphylococcus aureus.
11. The method of claim 10 , wherein the Staphylococcus aureus is methicillin-resistant.