Therapeutic renal neuromodulation for treating dyspnea and associated systems and methods
Methods for treating dyspnea with therapeutic renal neuromodulation and associated system and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods that block, reduce, and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympathetic nerve activity may be altered or modulated along the afferent and/or efferent pathway. The achieved reduction in central sympathetic tone may carry therapeutic benefits for patients with dyspnea.
1. A method of treating a human patient diagnosed with dyspnea, the method comprising:
intravascularly positioning a catheter carrying an energy transfer element within a renal artery and at least proximate renal nerves of the patient with diagnosed dyspnea,
wherein, before therapy, the patient has a measured hypercapnic ventilatory response above a threshold value of 3 L/min/mmHgCO 2 ;
ablating the renal nerves of the patient via energy from the energy transfer element,
wherein ablating the renal nerves at least partially reduces sympathetic neural activity in the renal nerves of the patient; and
reducing central sympathetic drive in the patient in a manner that treats the patient for the dyspnea and reduces the patient's sensitivity to pCO 2 such that the patient has a measured hypercapnic ventilatory response below the threshold value.
2. The method of claim 1 wherein reducing central sympathetic drive in a manner that treats the patient for the dyspnea comprises altering the patient's chemoreceptor set point.
3. The method of claim 1 wherein reducing central sympathetic drive in a manner that treats the patient for the dyspnea comprises changing the patient's gain in respiratory effort associated with increased pCO 2 .
4. The method of claim 1 wherein the dyspnea is associated with a condition comprising at least one of systolic heart failure, diastolic heart failure, congestive heart failure, panic disorders, chronic lung disease, acute lung disease, renal disease, deconditioning, and hypertension.
5. The method of claim 1 wherein ablating the renal nerves comprises thermally ablating the renal nerves.
6. The method of claim 5 wherein thermally ablating the renal nerves comprises necrosing the renal nerves via a cryoablation device.
7. The method of claim 5 wherein thermally ablating the renal nerves comprises delivering an energy field to the renal nerves via the energy transfer element.
8. The method of claim 1 wherein at least partially reducing sympathetic neural activity in the renal nerves of the patient comprises blocking afferent neural activity.
9. The method of claim 1 wherein at least partially reducing sympathetic neural activity in the renal nerves of the patient comprises blocking efferent neural activity.
10. The method of claim 1 wherein, before therapy, the patient has a measured hypercapnic ventilatory response above 12 L/min/mm/HgCO 2 .
11. The method of claim 1 wherein, before therapy, the patient has a measured hypercapnic ventilatory response from about 5 L/min/mm/HgCO 2 to about 12 L/min/mmHgCO 2 .
12. The method of claim 1 wherein, before therapy, the patient has a measured hypercapnic ventilatory response above 3 L/min/mmHgCO 2 to about 5 L/min/mmHgCO 2 .