IP Library Granted Patent US 9,198,911
Granted Patent B2
US 9,198,911 · App. 13/886,252 · Granted Dec 1, 2015

Methods for treating hair loss disorders

Inventors: Angela M. Christiano (Mahwah, NJ); Raphael Clynes (West Nyack, NY)
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
A61K31/52A61K31/407A61K31/506A61K31/519A61K31/63A61K31/7052A61K31/713
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Quick Facts
Patent No.
US 9,198,911
App. No.
13/886,252
Granted
Dec 1, 2015
Kind
B2
Abstract

The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.

Claims (12)

1. A method of treating a hair-loss disorder in a mammalian subject in need thereof, the method comprising administering to the subject INCB 018424.

2. The method of claim 1 , wherein the hair-loss disorder is selected from androgenetic alopecia, telogen effluvium, alopecia areata, tinea capitis, hypotrichosis, and hereditary hypotrichosis simplex.

3. The method of claim 2 , wherein the alopecia areata is alopecia totalis or alopecia universalis.

4. The method of claim 1 wherein the hair loss-disorder is androgenetic alopecia.

5. The method of claim 1 wherein the hair loss-disorder is alopecia areata.

6. A method for inducing hair growth in a subject, the method comprising:

(a) administering to the subject an effective amount of INCB 018424,

thereby inducing hair growth in the subject.

7. The method of claim 6 , wherein the subject suffers from a hair-loss disorder, wherein the hair-loss disorder is selected from androgenetic alopecia, telogen effluvium, alopecia areata, tinea capitis, hypotrichosis, and hereditary hypotrichosis simplex.

8. The method of claim 7 , wherein the alopecia areata is alopecia totalis or alopecia universalis.

9. The method of claim 7 wherein the hair loss-disorder is androgenetic alopecia.

10. The method of claim 7 wherein the hair loss-disorder is alopecia areata.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 8, 2018
From: CHRISTIANO, ANGELA M.; CLYNES, RAPHAEL
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 044870/0487 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 15, 2015
From: CHRISTIANO, ANGELA M.; CLYNES, RAPHAEL
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 036804/0826 →
CONFIRMATORY LICENSE Recorded Jul 29, 2013
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030918/0849 →
Continuity (6)
Continuation In Part PCTUS2011059029 · Nov 2, 2011
Continuation In Part PCTUS2013034688 · Mar 29, 2013
Provisional Application 61409509 · Nov 2, 2010
Provisional Application 61617225 · Mar 29, 2012
Provisional Application 61645499 · May 10, 2012
Related Publication 20140065153A1 · Mar 6, 2014