IP Library › Patent Application 13887797
Patent Application
App. No. 13/887,797

Toll-Like Receptor 3 Antagonists for the Treatment of Metabolic and Cardiovascular Diseases

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Quick Facts
Patent No.
US None
App. No.
13/887,797
Abstract

Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.

Claims (3)

1 . A method of treating a cardiovascular disease comprising administering a therapeutically effective amount of an isolated antibody reactive with TLR3 to a patient in need thereof for a time sufficient to treat the cardiovascular disease.

2 . The method of claim 1 , wherein the isolated antibody reactive with TLR3 antibody comprises heavy chain complementarity determining regions 1, 2 and 3 (HCDR1, HCDR2, HCDR3) having amino acid sequences shown in SEQ ID NOs: 70, 77 and 72 and light chain complementarity determining regions 1, 2 and 3 (LCDR1, LCDR2, LCDR3) having amino acid sequences shown in SEQ ID NOs: 67, 68 and 78.

3 . The method of claim 1 , wherein the isolated antibody reactive with TLR3 antibody comprises heavy chain complementarity determining regions 1, 2 and 3 (HCDR1, HCDR2, HCDR3) having amino acid sequences shown in SEQ ID NOs: 82, 86 and 84 and light chain complementarity determining regions 1, 2 and 3 (LCDR1, LCDR2, LCDR3) having amino acid sequences shown in SEQ ID NOs: 79, 80 and 87.