IP Library › Granted Patent US 8,906,938
Granted Patent B2
US 8,906,938 · App. 13/894,209 · Granted Dec 9, 2014

C5aR antagonists

Inventors: Pingchen Fan (Fremont, CA); Kevin Lloyd Greenman (Sunnyvale, CA); Manmohan Reddy Leleti (Sunnyvale, CA); Yandong Li (San Jose, CA); Jay P. Powers (Pacifica, CA); Hiroko Tanaka (Foster City, CA); Ju Yang (Cupertino, CA); Yibin Zeng (Foster City, CA)
Assignee: ChemoCentryx, Inc.
C07D211/60A61K31/454C07D413/14C07D401/10A61K31/5377C07D405/10C07D401/06A61K31/445C07D401/14A61K31/451C07D413/12A61K31/4545
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,906,938
App. No.
13/894,209
Granted
Dec 9, 2014
Kind
B2
Abstract

Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.

Claims (8)

1. A compound having the formula

or a pharmaceutically acceptable salt or rotamer thereof.

2. The compound of claim 1 , in a pharmaceutically acceptable salt form.

3. A composition comprising a pharmaceutically acceptable carrier and a compound having the formula:

or a pharmaceutically acceptable salt, hydrate or rotamer thereof.

4. A compound having the formula:

5. A pharmaceutical composition comprising a compound having the formula

and a pharmaceutically acceptable carrier.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2014
From: FAN, PINGCHEN; GREENMAN, KEVIN LLOYD; LELETI, MANMOHAN REDDY; LI, YANDONG; POWERS, JAY; TANAKA, HIROKO; YANG, JU; ZENG, YIBIN
To: CHEMOCENTRYX, INC.
Reel/Frame 034202/0484 →
Continuity (3)
Division 12643229 · Dec 21, 2009
Provisional Application 61139919 · Dec 22, 2008
Related Publication 20130317028A1 · Nov 28, 2013