METHOD OF TREATING HEMATOLOGICAL CANCERS
Methods and compositions for treating hematological cancer are disclosed, including refractory or resistant hematological cancer.
1 . Use of a compound that is a pharmaceutically acceptable salt of trans-[tetrachlorobis(1H-indazole)ruthenate(III)] for the manufacturing of a medicament for treating hematological cancer.
2 . The use of claim 1 , wherein said hematological cancer is lymphoma.
3 . The use of claim 2 , wherein said lymphoma is B cell lymphoma.
4 . The use of claim 3 , wherein said lymphoma is diffuse large B cell lymphoma, follicular lymphoma or mantle cell lymphoma.
5 . The use of claim 1 , wherein said hematological cancer is a refractory hematological cancer.
6 . The use of claim 5 , wherein said hematological cancer is leukemia refractory to a treatment comprising one or more drugs selected from the group consisting of doxorubicin, cytarabine and fludarabine.
7 . The use of claim 5 , wherein said hematological cancer is lymphoma refractory to a regimen comprising doxorubicin or melphalan or both, or a CHOP regimen or a RCHOP regimen.
8 . The use of claim 1 , wherein said compound is sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)].