Rosuvastatin and atorvastatin derivatives

1. A pharmaceutical composition comprising a composition of Formula I or a pharmaceutically acceptable salt or solvate thereof and a vehicle:

wherein:

A is

R 1b ,R 4b and one of R 2b and R 3b are each independently selected from the group consisting of: hydrogen, halo, C 1-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl, C 1-4 alkyl aryl, heterocyclyl, and C 1-4 alkyl heteroaryl;

and the other of R 2b and R 3b is —CONR 9b R 10b where R 9b and R 10b are independently selected from the group consisting of: hydrogen, C 1-6 alkyl, C 2-6 alkenyl, aryl, C 1-4 alkyl aryl, heteroaryl, and C 1-4 heteroaryl;

R 5 is selected from the group consisting of: hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl, C 1-6 alkyl aryl, C 1-6 alkanoyl aryl, heteroaryl, C 1-6 alkanoyl heteroaryl and C 1-6 alkyl heteroaryl;

R 6 is selected from the group consisting of: C 2-6 alkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl, heteroaryl and C 1-6 alkyl heteroaryl;

R 7 and R 8 are independently selected from the group consisting of: H, C 1-4 alkyl and halo;

X is —(CR a R b ) m (CR a ═CR b ) n(CR a R b ) o — where R a and R b are independently selected from the group consisting of: H, methyl, ethyl and halo and m, n, and o are independently 0, 1, 2, or 3 provided that m+n+o is not more than 3; and wherein

each of the above R groups may, where chemically possible, be independently optionally substituted by from 1 to 5 groups chosen independently at each occurrence from the groups consisting of: halo, C 1-3 alkyl, halo C 1-3 alkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, hydroxy, and cyano.

2. The composition of claim 1 , wherein R 1b is C 1-6 alkyl.

3. The composition of claim 1 , wherein R 2b is —CONR 9b R 10b where R 9b is H and R 10b is aryl.

4. The composition of claim 1 , wherein R 3b is aryl.

5. The composition of claim 1 , wherein R 4b is optionally substituted aryl.

6. The composition of claim 1 , wherein R lb is i-propyl, R 2b is —CONHPh, R 3b is phenyl and R 4b 4-fluorophenyl.

7. The composition of claim 1 , wherein R 5 is selected from the group consisting of: hydrogen, C 1-6 alkyl, aryl, C 1-6 alkyl aryl, C 1-6 alkanoyl aryl, heteroaryl, C 1-6 alkanoyl heteroaryl and C 1-6 alkyl heteroaryl.

8. The composition of claim 7 wherein R 5 is hydrogen.

9. The composition of claim 7 , wherein R 5 is selected from the group comprising:

—C 1 alkyl-Ph, —C 2 alkyl-Ph, —C 3 alkyl-Ph, and —C 4 alkyl-Ph.

10. The composition of claim 9 , wherein R 5 is benzyl.

11. The composition of claim 7 , wherein R 5 is C 1-6 alkanoyl pyridine.

12. The composition of claim 11 , wherein R 5 is 3-methanoyl pyridine.

13. The composition of claim 1 , wherein R 6 is selected from the group consisting of: C 2-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 3-6 cycloalkyl, aryl, heteroaryl and C 1-6 alkyl heteroaryl.

14. The composition of claim 13 , wherein R 6 is selected from the group consisting of: ethyl, propyl, butyl, chloromethyl, chloroethyl, chloropropyl, chlorobutyl and propylene.

15. The composition of claim 1 , wherein R 6 is optionally substituted aryl.

16. The composition of claim 15 , wherein R 6 is selected from the group consisting of: C 1-6 alkoxy substituted phenyl and halo substituted phenyl.

17. The composition of claim 16 , wherein R 6 is selected from the group consisting of: 2,4,6-trifluorophenyl and 2,4-dimethoxyphenyl.

18. The composition of claim 1 , wherein R 6 is selected from the group consisting of: C 2-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl and aryl.

19. The composition of claim 18 , wherein R 6 is selected from the group consisting of: ethyl, propyl, butyl, cyclohexyl and allyl.

20. The composition of claim 1 , wherein R 5 is hydrogen and R 6 is an optionally substituted aromatic group.

21. The composition of claim 1 , wherein R 5 is an optionally substituted benzyl and R 6 is an optionally substituted C 2-6 alkyl, an optionally substituted C 2-6 alkenyl or a C 1-6 haloalkyl.

22. The composition of claim 1 , wherein R 5 is a C 1-6 alkanoyl heteroaryl and R 6 is an optionally substituted C 2-6 alkyl.

23. The composition of claim 1 , wherein R 5 is hydrogen and R 6 is an C 2-6 alkyl, C 3-6 cycloalkyl or an optionally substituted aryl.

24. The composition of claim 1 , wherein R 7 is H and R 8 is H.

25. The composition of claim 1 , wherein R a is H, R b is H and m=0, n=1 and o=0; or

each R a is H, each R b is H and m=2, n=0 and o=0.

26. The composition of claim 1 in which the composition of Formula I has a structure selected from: