ORGAN PROTECTION, PRESERVATION AND RECOVERY
This application describes compositions, methods of treatment, and methods of manufacturing a medicament for reducing injury or damage to cells, tissues or organs during ischemia, reperfusion, or following ischemia or trauma. The methods for reducing damage to a cell, tissue or organ comprise administering an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; and (ii) an antiarrhythmic agent. The methods may further include postconditioning the cell, tissue or organ.
1 . A method for reducing damage to a cell, tissue or organ following ischemia comprising:
administering an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; and (ii) an antiarrhythmic agent; and
postconditioning the cell, tissue or organ.
2 . A method according to claim 1 , wherein the composition further includes a delta-1-opioid receptor agonist.
3 . A method according to claim 2 , wherein the opioid is [D-Pen 2,5]enkaphalin (DPDPE).
4 . A method according to claim 1 , wherein the adenosine receptor agonist is CCPA.
5 . A method for reducing damage to a cell, tissue or organ following trauma comprising:
administering an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; and (ii) an antiarrhythmic agent; and
postconditioning the cell, tissue or organ.
6 . A method for reducing damage to a cell, tissue or organ during ischemia or reperfusion:
administering an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; and (ii) an antiarrhythmic agent; and
postconditioning the cell, tissue or organ.
7 . A method for reducing damage to a cell, tissue or organ following ischemia comprising administering to the cell, tissue or organ an effective amount of a composition including (i) a potassium channel opener or agonist, and/or adenosine receptor agonist; (ii) an antiarrhythmic agent and (iii) an opioid.
8 . A method for reducing damages to a cell, tissue or organ following trauma, comprising administering to the cell, tissue or organ an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; (ii) an antiarrhythmic agent and (iii) an opioid.
9 . A method for reducing damage to a cell, tissue or organ during ischemia or reperfusion comprising administering to the cell, tissue or organ an effective amount of a composition including (i) a potassium channel opener or agonist and/or adenosine receptor agonist; (ii) an antiarrhythmic agent and (iii) an opioid.
10 . A method according to claim 7 , further including postconditioning the cell, tissue or organ.
11 . A composition for reducing damage to a cell, tissue or organ during ischemia or reperfusion or following ischemia or trauma comprising:
(i) a potassium channel opener or agonist and/or adenosine receptor agonist;
(ii) an antiarrhythmic agent; and
(iii) an opioid.
12 . A method according to claim 8 further including postconditioning the cell, tissue or organ.
13 . A method according to claim 9 further including postconditioning the cell, tissue or organ.