Urinary biomarkers for predicting long-term dialysis
View Patent ↗This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of hyaluronic acid can be used to determine whether a patient having suffered acute kidney injury will require long-term dialysis.
1. A method, comprising:
a) obtaining at least two urine samples from a patient exhibiting at least one symptom of an acute kidney injury said patient being asymptomatic for a chronic kidney disease, wherein said at least two urine samples comprise a first sample and a subsequent sample, wherein said first sample is collected within one day of initiation of a renal replacement therapy;
b) detecting hyaluronic acid in said at least two urine samples, wherein said hyaluronic acid in said subsequent sample is elevated as compared to said first sample; and
c) predicting said patient to require long-term dialysis within sixty days of said first sample.
2. The method of claim 1 , wherein said subsequent sample is collected on the fourteenth day after initiation of said replacement therapy.
3. The method of claim 1 , wherein said method further comprises diagnosing said patient with chronic kidney disease.
4. The method of claim 1 , wherein said method further comprises entering said patient in a chronic kidney disease prevention program.
5. The method of claim 1 , wherein said subsequent sample is collected on the seventh day after initiation of said replacement therapy.
6. The method of claim 1 , wherein said first sample is collected on the first day after initiation of said replacement therapy.
7. A method, comprising:
a) obtaining at least two urine samples derived from a patient exhibiting at least one symptom of an acute kidney injury said patient being asymptomatic of a chronic kidney disease, wherein said patient is at risk for development of said chronic kidney disease, wherein said at least two samples comprise a first sample and a subsequent sample, wherein said first sample is collected within one day of initiation of a renal replacement therapy;
b) detecting hyaluronic acid in said urine samples, wherein said hyaluronic acid in said subsequent sample is elevated as compared to said first sample; and
c) treating said patient to prevent said chronic kidney disease within sixty days after said first sample.
8. The method of claim 7 , wherein said treating is initiated on day 14 after the initiation of said renal replacement therapy.
9. A method, comprising:
a) obtaining a plurality of urinary hyaluronic acid and creatinine levels from a patient having suffered an acute kidney injury said patient being asymptomatic for a chronic kidney disease, wherein said levels are obtained over time;
b) constructing a urinary hyaluronic acid level time course, wherein said time course is normalized against said urinary creatinine levels; and
c) predicting said chronic kidney disease development.
10. The method of claim 9 , wherein said predicting includes long-term renal replacement therapy.