IP Library › Granted Patent US 8,754,236
Granted Patent B2
US 8,754,236 · App. 13/947,593 · Granted Jun 17, 2014

Compounds for preparing immunological adjuvant

Inventors: Francis G. Fang (Andover, MA); James E. Foy (Andover, MA); Lynn Hawkins (Concord, MA); Charles Lemelin (North Chelmsford, MA); Andre LesCarbeau (Sommerville, MA); Xiang Niu (Malden, MA); Kuo-Ming Wu (Acton, MA)
Assignee: Eisai R&D Management Co., Ltd.
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Quick Facts
Patent No.
US 8,754,236
App. No.
13/947,593
Granted
Jun 17, 2014
Kind
B2
Abstract

The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases. Also provided are synthetic intermediates.

Claims (5)

1. A compound of formula (18):

wherein:

R 4 is a C 5 -C 12 alkyl group or a C 5 -C 12 alkenyl group; and

R 5 is a C 5 -C 15 alkyl group or a C 5 -C 15 alkenyl group.

2. A compound of claim 1 , having the formula ER-819509

Continuity (5)
Division 13468634 · May 10, 2012
Division 12698686 · Feb 2, 2010
Division 11477936 · Jun 30, 2006
Provisional Application 60695324 · Jun 30, 2005
Related Publication 20140012011A1 · Jan 9, 2014