Method to enhance delivery of glutathione and ATP levels in cells
A therapeutic method is provided comprising treating a mammal subject to hypoxia with an amount of 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidine-4(R)-carboxylic acid (RibCys) or a pharmaceutically acceptable salt thereof effective to both maintain, restore or increase both the ATP levels and the glutathione (GSH) levels in said tissue.
1. A method of treating a tissue ischemia resulting from a surgical procedure in a mammal in need thereof by increasing glutathione and ATP comprising administering an effective amount of 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid, or a pharmaceutically acceptable salt thereof, to said mammal, wherein said 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid increases glutathione and ATP to treat said tissue ischemia resulting from the surgical procedure.
2. The method of claim 1 , wherein said 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid is administered orally or parenterally.
3. The method of claim 1 , wherein said 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid is administered orally.
4. The method of claim 1 , wherein said 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid is administered intravenously.
5. The method of claim 1 , wherein the surgical procedure is angioplasty, stenting, heart surgery, or organ transplantation.
6. The method of claim 1 , wherein said 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid is administered in a unit dosage form comprising 20% (w/w) of RibCys.
7. The method of claim 1 , wherein said 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid is administered in a liquid.
8. The method of claim 7 , wherein said liquid further comprises an effective amount of ribose to inhibit premature dissociation of the 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid.
9. The method of claim 7 , wherein said liquid comprises an effective amount of ribose to inhibit premature in vitro dissociation of the 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid.
10. The method of claim 1 , wherein said method consists of administering an effective amount of 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid or a pharmaceutically acceptable salt thereof to said mammal.
11. The method of claim 2 , wherein said 2(R,S)-D-ribo-(1′,2′,3′,4′-tetrahydroxybutyl)thiazolidone-4(R)-carboxylic acid is administered intravenously.
12. The method of claim 5 , wherein the heart surgery is heart bypass surgery or heart repair surgery.