Deuterium-enriched bupropion
The present application describes deuterium-enriched bupropion, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
1. A deuterium-enriched compound of Formula I or II:
or a pharmaceutically acceptable salt thereof, wherein:
each R 1 and R 3 -R 18 are independently H or D.
2. The compound of claim 1 , wherein the compound is a compound of Formula I.
3. The compound of claim 1 , wherein the compound is represented by:
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound is represented by:
5. The compound of claim 1 , wherein the compound is a compound of Formula II.
6. The compound of claim 1 , wherein the compound is represented by:
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , wherein the compound is represented by:
8. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
9. A pharmaceutical composition comprising a compound of claim 2 and a pharmaceutically acceptable carrier.
10. A pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier.
11. A pharmaceutical composition comprising a compound of claim 5 and a pharmaceutically acceptable carrier.
12. A pharmaceutical composition comprising a compound of claim 6 and a pharmaceutically acceptable carrier.
13. A method of treating depression, comprising administering a therapeutically effective amount of a compound of claim 1 to a patient in need thereof to treat the depression.
14. A method of treating depression, comprising administering a therapeutically effective amount of a compound of claim 2 to a patient in need thereof to treat the depression.
15. A method of treating depression, comprising administering a therapeutically effective amount of a compound of claim 3 to a patient in need thereof to treat the depression.
16. A method of treating depression, comprising administering a therapeutically effective amount of a compound of claim 5 to a patient in need thereof to treat the depression.
17. A method of treating depression, comprising administering a therapeutically effective amount of a compound of claim 6 to a patient in need thereof to treat the depression.
18. A method of treating a patient in need of smoking cessation, comprising administering a therapeutically effective amount of a compound of claim 1 to a patient in need thereof to ameliorate smoking by the patient.
19. A method of treating a patient in need of smoking cessation, comprising administering a therapeutically effective amount of a compound of claim 2 to a patient need thereof to ameliorate smoking by the patient.
20. A method of treating a patient in need of smoking cessation, comprising administering a therapeutically effective amount of a compound of claim 3 to a patient in need thereof to ameliorate smoking by the patient.
21. A method of treating a patient in need of smoking cessation, comprising administering a therapeutically effective amount of a compound of claim 5 to a patient in need thereof to ameliorate smoking by the patient.
22. A method of treating a patient in need of smoking cessation, comprising administering a therapeutically effective amount of a compound of claim 6 to a patient in need thereof to ameliorate smoking by the patient.