Skin external preparation and method of producing same
View Patent ↗A skin external preparation containing an ascorbic acid-2-phosphate derivative is characterized in that only a sodium ascorbic acid-2-phosphate-6-palmitate is formulated as the ascorbic acid-2-phosphate derivative, and the skin preparation further includes at least one betaine-type amphoteric surfactant selected from the group consisting of compounds represented by the following general formula (1) or (2) (wherein R 1 represents a linear or branched alkyl group of 6 to 30 carbon atoms, and R 2 represents a linear or branched alkyl group of 8 to 30 carbon atoms). R 1 —N + (CH 3 ) 2 —CH 2 COO − (1) R 2 —CONH—CH 2 —CH 2 —CH 2 —N + (CH 3 ) 2 —CH 2 COO − (2)
1. A skin external preparation comprising an ascorbic acid-2-phosphate derivative, characterized in that
only a sodium ascorbic acid-2-phosphate-6-palmitate is formulated as the ascorbic acid-2-phosphate derivative, and
the skin external preparation further comprises at least one betaine-type amphoteric surfactant selected from the group consisting of compounds represented by a general formula (1) or (2) shown below:
R 1 —N + (CH 3 ) 2 —CH 2 COO − (1)
R 2 —CONH—CH 2 —CH 2 —CH 2 —N + (CH 3 ) 2 —CH 2 COO − (2)
wherein R 1 represents a linear or branched alkyl group of 10 to 30 carbon atoms, and R 2 represents a linear or branched alkyl group of 8 to 30 carbon atoms.
2. The skin external preparation according to claim 1 , wherein at least one of the betaine-type amphoteric surfactantis a compound of the general formula (1) in which R 1 is a linear or branched alkyl group of 12 to 24 carbon atoms.
3. The skin external preparation according to claim 1 , wherein at least one of the betaine-type amphoteric surfactantis a compound of the general formula (2) in which R 2 is a linear or branched alkyl group of 12 to 24 carbon atoms.
4. The skin external preparation according to claim 1 , wherein a formulating amount of the sodium ascorbic acid-2-phosphate-6-palmitate is within a range from 0.01 to 10% by mass, relative to a total mass of the skin external preparation.
5. The skin external preparation according to claim 1 , wherein an amount of the betaine-type amphoteric surfactant is within a range from 0.1 to 10% by mass, relative to a total mass of the skin external preparation.
6. The skin external preparation according to claim 1 , wherein a pH of the skin external preparation is within a range from 6.5 to 7.5.
7. The skin external preparation according to claim 1 , wherein the skin external preparation is a cosmetic material.
8. A method of producing a skin external preparation comprising an ascorbic acid-2-phosphate derivative, the method comprising:
formulating: only a sodium ascorbic acid-2-phosphate-6-palmitate as the ascorbic acid-2-phosphate derivative; and at least one betaine-type amphoteric surfactant selected from the group consisting of compounds represented by a general formula (1) or (2) shown below:
R 1 —N + (CH 3 ) 2 —CH 2 COO − (1)
R 2 —CONH—CH 2 —CH 2 —CH 2 —N + (CH 3 ) 2 —CH 2 COO − (2)
wherein R 1 represents a linear or branched alkyl group of 10 to 30 carbon atoms, and R 2 represents a linear or branched alkyl group of 8 to 30 carbon atoms.
9. The method according to claim 8 , wherein the sodium ascorbic acid-2-phosphate-6-palmitate is formulated in an amount of 0.01 to 10% by mass, relative to a total mass of the skin external preparation.
10. The method according to claim 8 , wherein the betaine-type amphoteric surfactant is formulated in an amount of 0.1 to 10% by mass, relative to a total mass of the skin external preparation.