Active principle for mitigating undesired medical conditions
A composition for treating or preventing inflammatory-related conditions includes as an active principle a carrier which exhibits a plurality of a scavenger structure capable of mitigating the activity of a mediator of inflammatory-related conditions. The scavenger structure includes a nucleophilic center complying with the formula X 1 (—R″—)(—R′) m H n where: a) X 1 is a single-bonded heteroatom selected amongst N, O and S and exhibits a free electron pair; b) m is 0 or 1 and n is 1 or 2; c) —R″— is a bivalent organic group providing attachment to the carrier via one of its free valences and to X 1 at the other free valence; and d) R′— is a monovalent organic group attached to the X 1 via its free valence. A method for treating or preventing inflammatory-related conditions in an individual suffering from such conditions includes: providing the composition; and contacting the mediator within or separate from the individual.
1. A composition for treating or preventing inflammatory-related conditions comprising an active principle (=AP) comprising a polyvinyl alcohol carrier which exhibits a plurality of a scavenger structure which is capable of mitigating and/or neutralising the activity of a mediator of inflammatory-related conditions, said scavenger structure comprising carbazate as a nucleophilic centre, said AP being attached to a support made of a material selected from the group consisting plastic, glass, metal, mineral, ceramic and polymeric material.
2. The composition of claim 1 , wherein,
the scavenger structure of the polyvinyl alcohol carrier further comprises b) a second nucleophilic centre which exhibits a single-bonded first heteroatom N, O or S (═Y 1 ) and complies with formula III
Y 1 (—R″—)(—R′) m H n (formula III)
where:
a) Y 1 exhibits a free electron pair,
b) m is 0 or 1 and n is 1 or 2 with the sum of m plus n being 2 for Y 1 ═N and 1 for Y 1 ═S and O,
c) —R″— is a bivalent organic group providing attachment to the carrier via one of its free valences and direct attachment to the heteroatom Y 1 at the other one of its free valences, and
d) R′— is a monovalent organic group directly attached to the heteroatom Y 1 via its free valence; and
said first heteroatom Y 1 is capable of participating in an intramolecular addition reaction with a multiple bond formed when the carbazate is reacting with a keto or aldehyde carbon or a reactive multiple bond of an inflammatory related mediator.
3. The composition of claim 1 , wherein the support is made of a polymeric material selected from the group consisting of polysaccharides and polyester polymers.
4. The composition of claim 1 , wherein the AP is present in a concentration of 1 μg-100 mg/ml.
5. The composition of claim 1 , wherein the polyvinyl alcohol carrier has 200-600 monomeric units.
6. A composition for treating or preventing inflammatory-related conditions, comprising as an active principle (=AP) a polyvinyl alcohol carrier which exhibits a plurality of a scavenger structure which is capable of mitigating and/or neutralising the activity of a mediator of inflammatory-related conditions, said scavenger structure comprising carbazate as a nucleophilic centre, said polyvinyl alcohol being attached to polysaccharide support.
7. The composition of claim 6 , wherein the AP is present in a concentration of 1 μg-100 mg/ml.
8. The composition of claim 6 , wherein the polyvinyl alcohol carrier has 200-600 monomeric units.