Multifunctional chitosan grafted surfaces and uses thereof
The invention relates to a multifunctional chitosan grafted surface. Specifically, the invention relates to a chitosan modified with a quaternary ammonium salt (CH-Q) grafted surface that provides various functional properties, including stability (pH 3-9) and unique pH dependent swelling and antibacterial properties.
1. An article comprising an implantable medical device and a composition covalently and stably immobilized to a surface of the device, wherein said composition comprises a chitosan modified with a quaternary ammonium salt, wherein at least about 25% of saccharide monomers of the chitosan are modified with the quaternary ammonium salt, wherein the immobilized composition has a pH ranging from pH3 to pH 9, and exhibits reversible, pH-dependent swelling and contraction of the composition.
2. The article of claim 1 , wherein said composition further comprises an antimicrobial molecule.
3. The article of claim 1 , wherein said composition further comprises an adhesion resistance molecule.
4. The article of claim 1 , wherein said composition further comprises a molecule that prevents biocide leaching.
5. The article of claim 1 , wherein said chitosan is operably linked to an antimicrobial molecule, an adhesion resistance molecule, a molecule that prevents biocide leaching, or a combination thereof.
6. The article of claim 1 , wherein said surface is a silicon oxide surface.
7. The article of claim 1 , wherein about 25% of saccharide monomers of said chitosan are modified with a quaternary ammonium salt.
8. The article of claim 1 , wherein about 50% of saccharide monomers of said chitosan are modified with a quaternary ammonium salt.
9. The article of claim 1 , wherein said quaternary ammonium salt comprises chloride anions.
10. The article of claim 1 , wherein said quaternary ammonium salt is acetate anions.
11. The article of claim 1 , wherein said quaternary ammonium salt comprises citrate anions.
12. The article of claim 1 , wherein said article is a biomaterial.
13. The article of claim 1 , wherein said article is a biomedical device.
14. The article of claim 13 , wherein said biomedical device is a ventilator.
15. The article of claim 13 , wherein said biomedical device is an endotracheal tube.
16. The article of claim 13 , wherein said biomedical device is a device that comes in to contact with an environment in an animal.
17. The article of claim 13 , wherein said surface on said device provides antimicrobial capability.
18. A composition comprising a chitosan modified with a quaternary ammonium salt, wherein at least about 25% of saccharide monomers of the chitosan are modified with the quaternary ammonium salt, wherein the composition has a pH ranging from pH 3 to pH 9, and exhibits reversible, pH-dependent swelling and contraction, and wherein said composition is capable of being immobilized on a surface to provide an antimicrobial activity.
19. The article of claim 1 , wherein said composition is covalently immobilized to said surface via an amine group.
20. The article of claim 19 , wherein said amine is a primary amine group.