Cathepsin C inhibitors
View Patent ↗Disclosed are 4-amino-2-butenamides of Formula (I) having pharmacological activity, pharmaceutical compositions containing them, and methods for the treatment of diseases mediated by the cathepsin C enzyme such as chronic obstructive pulmonary disease.
1. A compound which is 4-amino-N-[(1S,2E)-4-(2,3-dihydro-1H-indol-1-yl)-1-(2-methylpropyl)-4-oxo-2-buten-1-yl]tetrahydro-2H-pyran-4-carboxamide, represented by the formula:
or a pharmaceutically acceptable salt thereof.
2. A compound which is 4-amino-N-[(1S,2E)-4-(2,3-dihydro-1H-indol-1-yl)-1-(2-methylpropyl)-4-oxo-2-buten-1-yl]tetrahydro-2H-pyran-4-carboxamide, represented by the formula:
3. A pharmaceutical composition which comprises the compound or salt according to claim 1 , and a pharmaceutically acceptable excipient.
4. A pharmaceutical composition which comprises the compound according to claim 2 , and a pharmaceutically acceptable excipient.
5. A process for preparing the composition as defined in claim 3 , the process comprising mixing the compound or salt with the pharmaceutically acceptable excipient.
6. A process for preparing the composition as defined in claim 4 , the process comprising mixing the compound with the pharmaceutically acceptable excipient.