Combination Therapy with a Gallium Complex
A combination therapy is disclosed for treating cancer. The method comprises identifying a patient diagnosed of cancer and in need of treatment, administering to a cancer patient a therapeutically effective amount of a compound of Formula (I), and administering to said patient a therapeutically effective amount of a certain second anti-cancer drug.
1 - 18 . (canceled)
19 . A method for treating or preventing cancer, said method comprising administering to a patient in need thereof a therapeutically effective amount of tris(8-quinolinolato)gallium(III), or a pharmaceutically acceptable salt thereof, in combination with one or more agents chosen from the group of 5-fluorouracil or a prodrug thereof, paclitaxel, Abraxane, docetaxel, gemcitabine, temsirolimus, temozolomide, erlotinib, lenalidomide and thalidomide.
20 . The method of claim 19 , wherein the 5-fluorouracil or prodrug thereof is selected from the group consisting of capecitabine, S1, and tegafur.
21 . A method for treating cancer, comprising administering to a patient in need of treatment of such cancer, simultaneously or sequentially, a therapeutically effective amount of (1) tris(8-quinolinolato)gallium(III), or a pharmaceutically acceptable salt thereof, and (2) temsirolimus.
22 . The method of claim 21 , wherein said cancer is lung cancer or renal cancer.
23 . A method for treating cancer, comprising administering to a patient in need of treatment of such cancer, simultaneously or sequentially, a therapeutically effective amount of (1) tris(8-quinolinolato)gallium(III), or a pharmaceutically acceptable salt thereof, and (2) temozolomide.
24 . The method of claim 23 , wherein said cancer is melanoma or brain cancer.
25 . A method for treating cancer, comprising administering to a patient in need of treatment of such cancer, simultaneously or sequentially, a therapeutically effective amount of (1) tris(8-quinolinolato)gallium(III), or a pharmaceutically acceptable salt thereof, and (2) lenalidomide or thalidomide.
26 . The method of claim 25 , wherein said cancer is multiple myeloma or MDS.
27 . A method for treating cancer, comprising administering sequentially to a patient in need of treatment a therapeutically effective amount of (1) paclitaxel or Abraxane and (2) tris(8-quinolinolato)gallium(III), or a pharmaceutically acceptable salt thereof.
28 . The method of claim 27 , wherein said cancer is lung cancer.
29 . A method for treating cancer, comprising administering sequentially to a patient in need of treatment a therapeutically effective amount of (1) tris(8-quinolinolato)gallium(III), or a pharmaceutically acceptable salt thereof, and (2) erlotinib.
30 . The method of claim 29 , wherein said cancer is lung cancer.