IP Library Granted Patent US 9,243,888
Granted Patent B2
US 9,243,888 · App. 13/991,657 · Granted Jan 26, 2016

Image mapped optical coherence tomography

Inventors: Tomasz S. Tkaczyk (Houston, TX); Mark Pierce (Piscataway, NJ)
Assignee: William Marsh Rice University
G01B9/02091A61B5/0066A61B5/6852G01J3/021G01J3/2823G01J3/453
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Quick Facts
Patent No.
US 9,243,888
App. No.
13/991,657
Granted
Jan 26, 2016
Kind
B2
Abstract

A method for imaging a sample. The method includes, during a single acquisition event, receiving depth-encoded electromagnetic (EM) fields from points on a sample that includes a first depth-encoded EM field for a first point and a second depth-encoded EM field for a second point, and redirecting the first depth-encoded EM field along a first predetermined direction to a first location on a dispersing re-imager and the second depthencoded EM field along a second pre-determined direction to a second location on the dispersing re-imager. The method further includes spectrally dispersing the first depthencoded EM field to obtain a first spectrum, re-imaging the first spectrum onto a first location on a detector, spectrally dispersing the second depth-encoded EM field to obtain a second spectrum, re-imaging the second spectrum onto a second location on the detector, and detecting the first re-imaged spectrum and the second re-imaged spectrum.

Claims (32)

1. A method for imaging a sample, comprising:

during a single acquisition event:

receiving a plurality of depth-encoded electromagnetic (EM) fields from a plurality of points on a sample comprising a first depth-encoded EM field for a first point and a second depth-encoded EM field for a second point;

redirecting the first depth-encoded EM field along a first pre-determined direction to a first location on a dispersing re-imager and the second depth-encoded EM field along a second pre-determined direction to a second location on the dispersing re-imager;

spectrally dispersing the first depth-encoded EM field to obtain a first spectrum;

re-imaging the first spectrum onto a first location on a detector;

spectrally dispersing the second depth-encoded EM field to obtain a second spectrum;

re-imaging the second spectrum onto a second location on the detector; and

detecting the first re-imaged spectrum and the second re-imaged spectrum.

2. The method of claim 1 , wherein the first depth-encoded EM field comprises a plurality of EM fields emanating along a z-direction in the sample for the first point.

3. A system, comprising:

an image mapper configured to, during a single acquisition event:

receive a plurality of depth-encoded electromagnetic (EM) fields from a plurality of points on a sample comprising a first depth-encoded EM field for a first point and a second depth-encoded EM field for a second point; and

redirect the first depth-encoded EM field along a first pre-determined direction to a first location on a dispersing re-imager and the second depth-encoded EM field along a second pre-determined direction to a second location on the dispersing re-imager;

the dispersing re-imager configured to:

spectrally disperse the first depth-encoded EM field to obtain a first spectrum;

re-image the first spectrum on to a first location on a detector;

spectrally disperse the second depth-encoded EM field to obtain a second spectrum; and

re-image the second spectrum on to a second location on the detector; and

the detector configured to:

detect the first re-imaged spectrum and the second re-imaged spectrum.

4. The system of claim 3 , further comprising:

a spectral domain optical coherence tomography (SD-OCT) system configured to generate the plurality of depth-encoded EM fields and provide the plurality of depth-encoded EM fields to the image mapper.

5. The system of claim 4 , further comprising:

a field lens interposed between the SD-OCT and the image mapper and configured to receive the plurality of depth-encoded EM fields from the SD-OCT.

6. The system of claim 3 , wherein the first depth-encoded EM field comprises a plurality of EM fields emanating along a z-direction in the sample for the first point.

7. The system of claim 3 , wherein the image mapper is refractive.

8. The system of claim 7 , wherein the dispersing re-imager comprises an array of field of view correctors configured to receive the plurality of depth-encoded EM fields from the image remapper and to shift each of the plurality of depth-encoded EM fields to obtained a plurality of shifted depth-encoded EM fields.

9. The system of claim 8 , wherein the dispersing re-imager further comprises an array of dispersive elements configured to receive the plurality of shifted depth-encoded EM fields and to spectrally disperse each of the plurality of spectra comprising the first spectrum and the second spectrum.

10. The system of claim 9 , wherein the dispersing re-imager further comprises an array of reimaging lenses configured to the plurality of spectra and to re-image the plurality of spectra on to the detector.

11. The system of claim 3 , wherein the detector comprises a two-dimensional (2D) array of EM radiation detectors.

12. The system of claim 11 , the detector is a charged-couple device.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 6, 2014
From: RICE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032365/0487 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 10, 2013
From: TKACZYK, TOMASZ S.; PIERCE, MARK
To: WILLIAM MARSH RICE UNIVERSITY
Reel/Frame 030580/0908 →
Continuity (2)
Provisional Application 61422053 · Dec 10, 2010
Related Publication 20130250290A1 · Sep 26, 2013