Method for producing refined polyrotaxane
The present invention aims to provide a method for producing a refined polyrotaxane which includes an industrially advantageous method of producing a polyrotaxane that has excellent storage stability. The method for producing a refined polyrotaxane includes the step of heat-cleaning a polyrotaxane with a cleaning medium, the polyrotaxane containing cyclodextrin molecules, a polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner, and a capping group that is placed at each end of the polyethylene glycol and prevents dissociation of the cyclodextrin molecules from the polyethylene glycol.
1. A method for producing a refined polyrotaxane, comprising:
mixing a polyethylene glycol and a cyclodextrin in an aqueous medium to form an aqueous dispersion of pseudopolyrotaxane that contains the polyethylene glycol which is included in the cavities of the cyclodextrin molecules in a skewered manner;
spray-drying the aqueous dispersion of pseudopolyrotaxane to obtain a powdery dry pseudopolyrotaxane; and
a capping step comprising dispersing the dry pseudopolyrotaxane in a medium that does not dissolve the pseudopolyrotaxane and introducing a capping group at each end of the polyethylene glycol of the pseudopolyrotaxane to produce polyrotaxanee; and
heat-cleaning the polyrotaxane with a cleaning medium.
2. The method for producing a refined polyrotaxane according to claim 1 ,
wherein the polyrotaxane is heat-cleaned at 40 to 120° C.
3. The method for producing a refined polyrotaxane according to claim 1 ,
wherein the cleaning medium weighs 5 to 100 times the polyrotaxane.
4. The method for producing a refined polyrotaxane according to claim 1 ,
wherein the cleaning medium is water.
5. The method for producing a refined polyrotaxane according to claim 1 ,
wherein the polyrotaxane has a volume average particle size of 1 to 3,000 μm.
6. The method for producing a refined polyrotaxane according to claim 1 ,
wherein the polyethylene glycol has a weight average molecular weight of 1,000 to 500,000.