Antibacterial agent for treating infectious diseases of bacterial origin
View Patent ↗The invention relates to medicine, namely to the antimicrobial agent for the treatment of infectious bacterial diseases including hospital infections and drug-resistant TB which represents the ion nanostructured complex (INSC) synthesized from carbohydrates proteins and/or polypeptides (albumins, interleukins, interferons, signaling proteins, etc), which are to enhance the antimicrobial activity in vivo, by activating immune cells that contain at least one terminal amino acid such as Phe, Ala, Val, Ala, Leu, Ile, and others with electron-donor functional groups, iodine and halides of the alkali and alkaline earth elements in the fourth stage at a certain ionic strength; an antibacterial agent increases: the susceptibility of bacteria, including antibiotic-resistant, to antibiotics; activity of monocytes and macrophages; efficiency of antibiotic treatment of hospital infections and drug-resistant TB; it also has antiviral activity, stimulates hematopoietic function of bone marrow; has an antitumor effect and radioprotective properties; in acceptable concentrations of components can be used as non-pharmaceutical agent (BAFS or parapharmaceutical); is presented in the pharmacological form suitable for parenteral, oral, external, or other application. INSC has the formula [{(Ln(MeI3)+)y[Me(Lm)I]+x}(Cl−)y+x+k] with M=30-300 kDa.
1. An ionic nanostructured complex composition, the composition comprising an adduct prepared by a reaction of:
(a) at least one carbohydrate composition selected from the group consisting of amylopectin, dextran, and dextrin;
(b) a protein composition comprising albumin and water;
(c) an iodine comprising iodine as iodine (I 2 ), potassium iodide, triiodide, or polyiodide;
(d) a polyvinyl alcohol; and
(e) a salt solution comprising water, at least one first alkali metal salt and at least one first alkaline earth metal salt,
wherein the salt solution optionally is pre-mixed with the at least one carbohydrate composition, the protein, or the polyvinyl alcohol.
2. An ionic nanostructured complex composition, the composition comprising an adduct prepared by a reaction of:
(a) at least one carbohydrate composition selected from the group consisting of amylopectin, dextran, and dextrin;
(b) a protein composition comprising albumin and water;
(c) a first iodine comprising iodine as iodine (I 2 ), potassium iodide, triiodide, or polyiodide;
(d) a polyvinyl alcohol;
(e) at least one immunotropic protein comprising interleukin-2 having at least one chain terminal amino acid with electron donor functional groups;
(f) a second iodine comprising iodine as iodine (I 2 ), potassium iodide, triiodide, or polyiodide; and
(g) a salt solution comprising water, at least one first alkali metal salt and at least one first alkaline earth metal salt,
wherein the salt solution optionally is pre-mixed with the at least one carbohydrate composition, the protein, or the polyvinyl alcohol, and wherein the at least one chain terminal amino acid with electron donor functional groups is selected from the group consisting of phenylalanine, alanine, valine, leucine, and isoleucine.
3. An ionic nanostructured complex composition, the composition comprising an adduct prepared by a reaction of:
(a) at least one carbohydrate composition selected from the group consisting of amylopectin, dextran, and dextrin;
(b) a protein composition comprising albumin and water;
(c) a first iodine comprising iodine as iodine ( 12 ), potassium iodide, triiodide, or polyiodide;
(d) a polyvinyl alcohol;
(e) at least one immunotropic protein comprising interleukin-2 having at least one chain terminal amino acid with electron donor functional groups;
(f) a second iodine comprising iodine as iodine (I 2 ), potassium iodide, triiodide, or polyiodide; and
(g) a salt solution comprising water, at least one first alkali metal salt and at least one first alkaline earth metal salt,
wherein the salt solution optionally is pre-mixed with the at least one carbohydrate composition, the protein, or the polyvinyl alcohol, and wherein the at least one chain terminal amino acid with electron donor functional groups is selected from the group consisting of serine, threonine, cysteine, methionine, tyrosine, tryptophan, aspartic acid, glutamic acid, asparagine, glutamine, histidine, lysine, and arginine.
4. An ionic nanostructured complex composition, the composition comprising an adduct prepared by a reaction of:
(a) lithium chloride or sodium chloride;
(b) magnesium dichloride or calcium dichloride;
(c) amylum;
(c) polyvinyl alcohol;
(e) albumin; and
(f) potassium iodide comprising one or more iodine molecules, wherein the ionic nanostructured complex comprises:
(g) lithium chloride and magnesium dichloride; or
(h) lithium chloride and calcium dichloride; or
(i) sodium chloride; and magnesium dichloride; or
(j) sodium chloride and calcium dichloride,
and wherein the ionic nanostructured complex of the ionic nanostructured complex composition intercalates with the one or more iodine molecules.
5. An ionic nanostructured complex composition, the composition comprising an adduct prepared by a reaction of:
(a) lithium chloride and sodium chloride;
(b) magnesium dichloride and calcium dichloride;
(c) amylum;
(c) polyvinyl alcohol;
(e) albumin; and
(f) potassium iodide comprising one or more iodine molecules,
wherein the ionic nanostructured complex of the ionic nanostructured complex composition comprises lithium chloride, magnesium dichloride, sodium chloride and calcium dichloride, and wherein the ionic nanostructured complex of the ionic nanostructured complex composition intercalates with the one or more iodine molecules.