Electrode pad used for iontophoresis treatment
The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.
1. An electrode pad used for iontophoresis treatment comprising:
a base sheet;
an electrode placed on the base sheet;
an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed;
a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet such that a first surface of the medicament reservoir is in direct contact with the electrode, and such that a second surface of the medicament reservoir is arranged to be in direct contact with human skin, the first and second surfaces being opposite surfaces of the medicament reservoir; and
an insulating film, wherein:
the electrode pad has a boundary surface portion at which an inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir directly contact each other, and the boundary surface portion is covered with the insulating film such that a first surface of the insulating film is in direct contact with the adhesive sheet and the medicament reservoir, and such that a second surface of the insulating film is arranged to be in direct contact with human skin, the first and second surfaces of the insulating film being opposite surfaces; and
the boundary surface portion is prevented from coming into contact with human skin by the insulating film, and thereby skin irritation is reduced.
2. The electrode pad according to claim 1 , wherein the opening of the adhesive sheet is circular and the insulating film is ring-shaped with a width of 1 to 10 mm.
3. An electrode pad used for iontophoresis treatment in which the electrode pad is connected to an anode of a power supply and another pad which does not include medicament is connected to a cathode of the power supply, the electrode pad comprising: a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed, the electrode pad being adhered to human skin using only the adhesive sheet; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet such that a first surface of the medicament reservoir is in direct contact with the electrode, and such that a second surface of the medicament reservoir is arranged to be in direct contact with human skin, the first and second surfaces being opposite surfaces of the medicament reservoir, wherein: a predetermined space (r) is provided between an inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir, the space (r) being an empty space, such that the inner peripheral surface of the opening of the adhesive sheet and the outer peripheral surface of the medicament reservoir are prevented from coming into contact with each other while contacting human skin, and thereby skin irritation is reduced; and a thickness of the adhesive sheet and a thickness of the medicament reservoir are made substantially equal to each other.
4. The electrode pad according to claim 3 , wherein the space (r) is 1 to 10 mm.
5. An electrode pad used for iontophoresis treatment in which the electrode pad is connected to an anode of a power supply and another pad which does not include medicament is connected to a cathode of the power supply, the electrode pad comprising: a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed, the electrode pad being adhered to human skin using only the adhesive sheet; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet such that a first surface of the medicament reservoir is in direct contact with the electrode, and such that a second surface of the medicament reservoir is arranged to be in direct contact with human skin, the first and second surfaces being opposite surfaces of the medicament reservoir, wherein: a predetermined space (r) is provided between an inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir, the space (r) being an empty space, such that the inner peripheral surface of the opening of the adhesive sheet and the outer peripheral surface of the medicament reservoir are prevented from coming into contact with each other while contacting human skin, and thereby skin irritation is reduced; and the medicament reservoir is dome shaped, and a height of the dome shaped medicament reservoir is greater than a thickness of the adhesive sheet.
6. The electrode pad according to claim 5 , wherein at any point on a surface of the medicament reservoir which comes into contact with the human skin, a sum of electric resistance of the medicament reservoir itself and contact electric resistance due to contact pressure with the human skin at that point is constant throughout an entire surface of the medicament reservoir.