Histone acetyltransferase modulators and uses thereof
The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a subject.
1. A compound of any one of the formulae below:
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition, comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier.
4. A pharmaceutical composition, comprising a compound of claim 2 , or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier.
5. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
12. A pharmaceutical composition, comprising the compound of claim 5 , and at least one pharmaceutically acceptable carrier.
13. A pharmaceutical composition, comprising the compound of claim 6 , and at least one pharmaceutically acceptable carrier.
14. A pharmaceutical composition, comprising the compound of claim 7 , and at least one pharmaceutically acceptable carrier.
15. A pharmaceutical composition, comprising the compound of claim 8 , and at least one pharmaceutically acceptable carrier.
16. A pharmaceutical composition, comprising the compound of claim 9 , and at least one pharmaceutically acceptable carrier.
17. A pharmaceutical composition, comprising the compound of claim 10 , and at least one pharmaceutically acceptable carrier.
18. A pharmaceutical composition, comprising the compound of claim 11 , and at least one pharmaceutically acceptable carrier.