Therapeutic agent for tumor
A therapeutic agent for tumor for combined use of a compound or pharmaceutically acceptable salt thereof represented by Formula (I) and a compound represented by Formula (II): wherein R 1 is C 1-6 alkyl or C 3-8 cycloalkyl, R 2 is a hydrogen atom or C 1-6 alkoxy, and R 3 is a hydrogen atom or a halogen atom, exhibits an excellent antitumor effect compared to cases where these are individually used.
1. A method of treating a tumor, comprising administering to a patient in need thereof a combination of:
a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof:
wherein R l is C 1-6 alkyl or C 3-8 cycloalkyl,
R 2 is a hydrogen atom or C 1-6 alkoxy, and
R 3 is a hydrogen atom or a halogen atom; and
a compound represented by Formula (II):
2. A pharmaceutical composition comprising:
a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof:
wherein R l is C 1-6 alkyl or C 3-8 cycloalkyl,
R 2 is a hydrogen atom or C 1-6 alkoxy, and
R 3 is a hydrogen atom or a halogen atom; and
a compound represented by Formula (II):
3. The method of claim 1 , wherein the compound represented by Formula (I) is selected from the group consisting of:
4-[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide:
4-[3-chloro-4-(methylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide:
4-[3-chloro-4-(ethylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide:
N6-methoxy-4-(3-chloro-4-{[(cyclopropylamino)carbonyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide:
and
N6-methoxy-4-(3-chloro-4-{[(ethylamino)carbonyl]amino}phenoxy)-7-methoxy-6-quinolinecarboxamide:
4. The method of claim 1 , wherein the compound represented by Formula (I) is 4-[3-chloro-4-(clopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide:
5. The method of claim 1 , comprising simultaneous administration of the compound represented by Formula (I), or a pharmaceutically acceptable salt thereof, and the compound represented by Formula (II).
6. The method of claim 1 , comprising separate administration of the compound represented by Formula (I), or a pharmaceutically acceptable salt thereof, and the compound represented by Formula (II).
7. The method of claim 1 , wherein the tumor is thyroid cancer, lung cancer, melanoma, endometrial cancer, gastric cancer, bladder cancer, renal cancer, glioma, liver cancer, or ovarian cancer.
8. The method of claim 1 , wherein the tumor is melanoma.
9. The pharmaceutical composition of claim 2 , wherein the compound represented by Formula (I) is selected from the group consisting of:
4- [3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy -6-quinolinecarboxamide:
4-[3-chloro-4-(methylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide:
4-[3-chloro-4-(ethylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide:
N6-methoxy-4-(3-chloro-4-{[(cyclopropylamino)carbonyl)amino]phenoxy}-7-methoxy-6-quinolinecarboxamide:
and
N6-methoxy-4-(3-chloro-4-{[(ethylamino)carbonyl]amino}phenoxy)-7-methoxy-6-quinolinecarboxamide:
10. The pharmaceutical composition of claim 2 , wherein the compound represented by Formula (I) is 4 -[3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]-7-methoxy-6-quinolinecarboxamide: