Quinolinone derivatives

1. A compound of formula (I) or a salt thereof:

wherein:

R 1 is a) a 5-membered heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from —CH 3 , —OCH 3 , —OH, —CH 2 OH, —CF 3 , —OCF 3 , —CN, —CO 2 H, —CH 2 CO 2 H, —CONH 2 , —NH 2 and halogen;

b) O-phenyl optionally substituted with a group selected from methyl, methoxy, fluoro, and CO 2 H;

c) selected from the group consisting of H, CO 2 H, CO 2 Et, and NO 2 ;

d) phenyl optionally substituted with a group selected from CO 2 H, Cl, F, methyl, —CN, -NMe 2 and methoxy;

e) selected from the group consisting of 3-pyridinyl, 4-pyridinyl, and —S(O) n -phenyl; or

f) selected from the group consisting of O-pyridin-2-yl, O-(4-methyl-pyridin-2-yl), O-(5-methoxy-pyridin-2-yl) and O-(5-methyl-pyridin-2-yl);

n=0 or 2;

R 2 is H;

R 3 is

R 4 is Cl;

R 5 is H; and

R 7 is H and R 6 is selected from a group consisting of, —NHMe, —NMe 2 , —NHC(O)OMe, —OMe, —OEt, Et, iPr, —CH 2 OH, and —CH 2 CH 2 OH or is a group selected from

or

R 6 and R 7 taken together form a group selected from

or

wherein:

i) R 1 =3-methoxyphenyl, R 4 is F and R 3 =4-(4-morpholino)phenyl;

ii) R 1 =3-methylisoxazol-5-yl, and R 3 =3-dimethylaminophenyl; or

iii) R 1 =3-methoxyphenyl, and R 3 =3-dimethylaminophenyl.

2. The compound or salt thereof according to claim 1 wherein R 1 represents 5-membered heteroaryl optionally substituted by a group selected from —CH 3 , —OCH 3 , —OH, —CH 2 OH, —CF 3 , —OCF 3 , —CN, —CO 2 H, —CH 2 CO 2 H, —CONH 2 , —NH 2 and halogen.

3. The compound or salt thereof according to claim 1 wherein R 1 represents 5-membered heteroaryl optionally substituted with 1, 2, or 3 groups independently selected from methyl, chloro, bromo, CO 2 H and methoxy.

4. The compound or salt thereof according to claim 1 wherein R 3 represents

5. The compound or salt thereof according to claim 1 wherein R 3 represents

6. A compound of formula (A) or a salt thereof:

wherein

R 1 represents 5-membered heteroaryl optionally substituted by —CH 3 , —OCH 3 , —OH, —CH 2 OH, —CF 3 , —OCF 3 , —CN, —CO 2 H, —CH 2 CO 2 H, —CONH 2 , —NH 2 or halogen;

R 2 represents H;

R 3 is

R 4 represents chloro;

R 5 represents H; and

R 7 is H and R 6 is selected from a group consisting of —NHMe, —NMe 2 , —NHC(O)OMe, Et, and iPr, or is a group selected from

7. The compound or salt thereof according to claim 1 , selected from the group consisting of:

7-Chloro-4-hydroxy-6-(2′-hydroxy-3′-methoxy-[1,1′-biphenyl]-4-yl)-3-phenylquinolin-2(1H)-one;

3-{7-Chloro-4-hydroxy-6-[2′-hydroxy-3′-(methyloxy)-4-biphenylyl]-2-oxo-1,2-dihydro-3-quinolinyl}benzoic acid;

7-chloro-4-hydroxy-3-(3-methoxyphenyl)-6-(4-morpholinophenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-3-phenylquinolin-2(1H)-one;

4-{7-Chloro-4-hydroxy-3-[3-(methyloxy)phenyl]-2-oxo-1,2-dihydro-6-quinolinyl}-N-cyclopentylbenzamide;

7-Fluoro-4-hydroxy-3-(3-methoxyphenyl)-6-(4-morpholinophenyl)quinolin-2(1H)-one;

3-[7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-2-oxo-1,2-dihydro-3-quinolinyl]benzoic acid;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-[3-(methyloxy)phenyl]quinolin-2(1H)-one;

N-{4-[4-(7-Chloro-4-hydroxy-2-oxo-3-phenyl-1,2-dihydro-6-quinolinyl)phenyl]-1,3-thiazol-2-yl}acetamide;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-phenylquinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)-6-(4-(piperidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(1-methyl-1H-pyrazol-4-yl)-6-(4-(piperidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-6-(4′-fluoro-[1,1′-biphenyl]-4-yl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(3′-methoxy-[1,1′-biphenyl]-4-yl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)-6-(4-(5-methylthiophen-2-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4′-methoxy-[1,1′-biphenyl]-4-yl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-6-(2′-fluoro-[1,1′-biphenyl]-4-yl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

3-(7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)benzonitrile;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(3-methyl-1,2,4-oxadiazol-5-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-3,6-bis(4-(dimethylamino)phenyl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-3-(4-cyanophenyl)-6-(4-(dimethylamino)phenyl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(5-methyl-1,3,4-oxadiazol-2-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(2-methylthiazol-5-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(2,4-dimethylthiazol-5-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-3-(5-methyl-1,3,4-oxadiazol-2-yl)-2-oxo-6-(4-(piperidin-1-yl)phenyl)-1,2-dihydroquinolin-4-olate;

Ethyl 7-chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-2-oxo-1,2-dihydro-3-quinolinecarboxylate;

Ethyl 7-chloro-4-hydroxy-6-[2′-hydroxy-3′-(methyloxy)-4-biphenylyl]-2-oxo-1,2-dihydro-3-quinoline carboxylate;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-nitroquinolin-2(1H)-one;

Ethyl 7-chloro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-2-oxo-1,2-dihydro-3-quinolinecarboxylate;

7-Chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)-6-(4-morpholino phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methoxyphenyl)-6-(4-(piperidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methoxyphenyl)-6-(1-methyl-1H-benzo [d]imidazol-6-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methoxyphenyl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

Methyl (4-(7-chloro-4-hydroxy-3-(3-methoxyphenyl)-2-oxo-1,2-dihydroquinolin-6-yl)phenyl) carbamate;

7-Chloro-6-[4-(dimethylamino)phenyl]-4-hydroxy-3-[3-(methyloxy)phenyl]quinolin-2(1H)-one;

7-Chloro-6-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-3-(3-methoxyphenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methoxyphenyl)-6-(4-(4-methylpiperazin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-6-(4-ethylphenyl)-4-hydroxy-3-(3-methoxyphenyl)quinolin-2(1H)-one;

7-Chloro-6-[3-(dimethylamino) phenyl]-4-hydroxy-3-[3-(methyloxy)phenyl]-2(1H)-quinolinone;

7-Chloro-6-(3-(dimethylamino)phenyl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-ethylphenyl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(2′-hydroxy-3′-methoxy-[1,1′-biphenyl]-4-yl)-3-(3-methylisoxazol-5-yl) quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-morpholinophenyl)-3-phenoxyquinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-phenylquinolin-2(1H)-one;

6-(4-(1H-Pyrazol-1-yl)phenyl)-7-chloro-4-hydroxy-3-phenylquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-methoxyphenyl)-3-phenylquinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-morpholinophenyl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-phenoxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-phenyl-6-(4-(piperidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(2-hydroxyethyl)phenyl)-3-phenylquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(3-hydroxypiperidin-1-yl)phenyl)-3-(3-methoxyphenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(2′-hydroxy-3′-methoxy-[1,1′-biphenyl]-4-yl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methoxyphenyl)-6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-phenyl-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(2′-hydroxy-3′-methoxy-[1,1′-biphenyl]-4-yl)-3-phenoxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(2′-hydroxy-3′-methoxy-[1,1′-biphenyl]-4-yl)quinolin-2(1H)-one;

N-(4-(4-(7-Chloro-4-hydroxy-2-oxo-3-phenoxy-1,2-dihydroquinolin-6-yl)phenyl)thiazol-2-yl) acetamide;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(o-tolyloxy)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(4-methoxyphenoxyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(hydroxymethyl)phenyl)-3-phenylquinolin-2(1H)-one;

7-Chloro-3-(3-fluorophenoxy)-4-hydroxy-6-(4-isopropylphenyl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(3-fluorophenoxy)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(methylamino)phenyl)-3-phenylquinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(1H-pyrazol-1-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-6-(4-ethoxyphenyl)-4-hydroxy-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-phenoxy-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-6-(4-ethylphenyl)-4-hydroxy-3-phenoxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-isopropylphenyl)-3-phenoxyquinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(3-methoxyphenoxyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methoxyphenoxy)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-isopropylphenyl)-3-(3-methoxyphenoxyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(cyclopropylmethoxy)phenyl)-4-hydroxy-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)-3-(1H-pyrazol-1-yl) quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indazol-5-yl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-isopropylphenyl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(p-tolyloxy)quinolin-2(1H)-one;

7-Chloro-6-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(4-methyl-1,2,5-oxadiazol-3-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(pyridin-4-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(pyridin-2-yloxy)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(1H-1,2,4-triazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(2-methoxyphenoxyl)quinolin-2 (1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(1H-1,2,3-triazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(4-methyl-1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(m-tolyloxy)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(pyridin-3-yl)quinolin-2(1H)-one;

3-((7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)oxy) benzoic acid;

1-(7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1H-pyrazole-4-carboxylic acid;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(4-fluorophenoxy)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(2′-hydroxy-[1, 1′-biphenyl]-4-yl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-3-(1,3-dimethyl-1H-pyrazol-5-yl)-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(piperidin-1-yl)phenyl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-((4-methylpyridin-2-yl)oxy)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-methoxyphenyl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(pyridin-3-yl)quinolin-2(1H)-one;

1-(7-Chloro-4-hydroxy-2-oxo-6-(4-(pyrrolidin-1-yl)phenyl)-1,2-dihydroquinolin-3-yl)-1H-pyrazole-4-carboxylic acid;

7-Chloro-4-hydroxy-3-(pyridin-3-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(4-methyl-1,2,5-oxadiazol-3-yl)-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(4-methyl-1,2,5-oxadiazol-3-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2 (1H)-one;

7-Chloro-4-hydroxy-3-(pyridin-4-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(4-methyl-1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(pyridin-4-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-phenoxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(2-methoxyphenoxy)-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(p-tolyloxy)quinolin-2(1H)-one;

7-Chloro-3-(3-fluorophenoxy)-4-hydroxy-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

6-([1,1′-Biphenyl]-4-yl)-7-chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-cyclohexylphenyl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(5-methyl-1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(5-methyl-1H-pyrazol-1-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2 (1H)-one;

7-Chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)-6-(naphthalen-2-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(3-hydroxypiperidin-1-yl)phenyl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(phenylthio)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-morpholinophenyl)-3-(phenylthio)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(hydroxymethyl)phenyl)-3-(phenylthio)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(6-methoxynaphthalen-2-yl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-methoxyphenyl)-3-phenoxyquinolin-2(1H)-one;

6-(4-(1H-Pyrazol-1-yl)phenyl)-7-chloro-4-hydroxy-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1H-indol-5-yl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-3-(1,3-dimethyl-1H-pyrazol-5-yl)-4-hydroxy-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-3-(4-chloro-1H-pyrazol-1-yl)-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(3-methoxyphenoxy)-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-3-(1,3-dimethyl-1H-pyrazol-5-yl)-4-hydroxy-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(1H-1,2,4-triazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(1-methyl-1H-pyrazol-4-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-((5-methylpyridin-2-yl)oxy)quinolin-2(1H)-one;

7-Chloro-3-(4-chloro-1H-pyrazol-1-yl)-4-hydroxy-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(pyrrolidin-1-yl)phenyl)-3-(1H-1,2,4-triazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(piperidin-1-yl)phenyl)-3-(1H-1,2,4-triazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(3-fluorophenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(methylamino)phenyl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(4-methyl-1H-pyrazol-1-yl)-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(4-methyl-1H-pyrazol-1-yl)-6-(4-(piperidin-1-yl)phenyl)quinolin-2 (1H)-one;

7-Chloro-4-hydroxy-6-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(1-ethyl-1H-indol-5-yl)-4-hydroxy-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(4-methyl-1,2,5-oxadiazol-3-yl)-6-(4-(piperidin-1-yl)phenyl)quinolin-2 (1H)-one;

7-Chloro-4-hydroxy-6-(4-(piperidin-1-yl)phenyl)-3-(pyridin-3-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-nitroquinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(phenylsulfonyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)-3-(phenylsulfonyl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(4-fluorophenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(o-tolyl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(2-methoxyphenyl)quinolin-2(1H)-one;

7-Chloro-3-(4-chlorophenyl)-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-3-(3-chlorophenyl)-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-3-(2-chlorophenyl)-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-3-(2-fluoro phenyl)-4-hydroxyquinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-6-yl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methylindolin-5-yl)-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(4-methoxy-1H-pyrazol-1-yl)-6-(4-(piperidin-1-yl)phenyl)quinolin-2 (1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(m-tolyl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(p-tolyl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-3-(2-methoxyphenoxy) quinolin-2(1H)-one;

7-chloro-4-hydroxy-6-(4-(1-(hydroxymethyl)cyclopropyl)phenyl)-3-(4-methoxy-1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(1-(hydroxymethyl)cyclopentyl)phenyl)-3-(3-methylisoxazol-5-yl) quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(4-methoxyphenyl) quinolin-2(1H)-one;

Methyl 1-(4-(7-chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)-2-oxo-1,2-dihydroquinolin-6-yl)phenyl)cyclopropane carboxylate;

7-Chloro-3-(3-chlorophenyl)-4-hydroxy-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-3-(3-chlorophenyl)-4-hydroxy-6-(4-(pyrrolidin-1-yl)phenyl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(4-methoxy-1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(1-(hydroxymethyl)cyclobutyl)phenyl)-3-(3-methylisoxazol-5-yl) quinolin-2(1H)-one;

7-Chloro-6-(4-(1-hydroxycyclobutyl)phenyl)-3-(3-methylisoxazol-5-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-6-(1-ethyl-1H-indol-5-yl)-3-(3-methylisoxazol-5-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-6-(4-ethoxyphenyl)-3-(3-methylisoxazol-5-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-6-(4-(3-hydroxyoxetan-3-yl)phenyl)-3-(3-methylisoxazol-5-yl)-2-oxo-1,2-dihydroquinolin-4-olate;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(3-methyl-1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-((4-methoxypyridin-2-yl)oxy)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-3-(4-methoxyphenoxy)-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-((5-methylpyridin-2-yl)oxy)quinolin-2(1H)-one;

7-Chloro-6-(2′-fluoro-[1,1′-biphenyl]-4-yl)-4-hydroxy-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(4-(5-methylthiophen-2-yl)phenyl)-3-(1H-pyrazol-1-yl)quinolin-2(1H)-one;

3-(4-Bromo-1H-pyrazol-1-yl)-7-chloro-6-(4-(dimethylamino)phenyl)-4-hydroxyquinolin-2(1H)-one;

3-(4-Bromo-1H-pyrazol-1-yl)-7-chloro-4-hydroxy-6-(4-(piperidin-1-yl)phenyl)quinolin-2 (1H)-one;

6-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]-7-chloro-4-hydroxy-3-phenylquinolin-2(1H)-one;

6-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]-7-chloro-4-hydroxy-3-[3-(methyloxy)phenyl]quinolin-2(1H)-one;

6-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)-7-chloro-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one;

6-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)-7-chloro-4-hydroxy-3-(3-methoxyphenyl)quinolin-2(1H)-one;

6-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)-7-chloro-4-hydroxy-3-(pyridin-3-yl)quinolin-2(1H)-one;

6-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]-7-chloro-4-hydroxy-3-(1H-pyrazol-1-yl)-2(1H)-quinolinone;

6-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)-7-chloro-4-hydroxy-3-(pyridin-4-yl)quinolin-2(1H)-one;

6-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)-7-chloro-4-hydroxy-3-(4-methyl-1H-pyrazol-1-yl) quinolin-2(1H)-one;

6-(4-(2-Amino-1,3-thiazol-4-yl)phenyl)-7-chloro-4-hydroxy-3-(1H-1,2,3-triazol-1-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-(1-methyl-1H-indol-5-yl)quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]quinolin-2(1H)-one;

7-Chloro-4-hydroxy-6-[2′-hydroxy-3′-(methyloxy)-4-biphenylyl]-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid;

1-(4-(7-Chloro-3-(3-methylisoxazol-5-yl)-4-oxido-2-oxo-1,2-dihydroquinolin-6-yl)phenyl)cyclopropanecarboxylate;

1-(7-Chloro-4-oxido-2-oxo-6-(4-(piperidin-1-yl)phenyl)-1,2-dihydroquinolin-3-yl)-1H-pyrazole-4-carboxylate; and

7-Chloro-3-(3-chlorophenyl)-4-hydroxy-6-(4-(piperidin-1-yl)phenyl) quinolin-2(1H)-one;

or a pharmaceutically acceptable salt thereof.

8. The compound or salt thereof according to claim 1 wherein the salt is a pharmaceutically acceptable salt.

9. A compound which is 7-chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one, represented by the formula:

or a pharmaceutically acceptable salt thereof.

10. The compound according to claim 9 which is 7-chloro-6-(4-(dimethylamino)phenyl)-4-hydroxy-3-(3-methylisoxazol-5-yl)quinolin-2(1H)-one, represented by the formula:

11. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt thereof according to claim 8 and a pharmaceutically acceptable carrier.

12. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt thereof according to claim 9 and a pharmaceutically acceptable carrier.

13. A pharmaceutical composition comprising the compound according to claim 10 and a pharmaceutically acceptable carrier.