Granted Patent
B2
US 9,056,835 · App. 14/011,739 · Granted Jun 16, 2015
LPA
Inventors:
Renukadevi Patil (Germantown, TN); James Fells (Memphis, TN); Duane D. Miller (Germantown, TN); Gabor Tigyi (Memphis, TN)
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Abstract
Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA 2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives.
Claims (8)
1. A compound of Formula I
wherein A is
R is H or substituted or unsubstituted phenyl;
R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are independently H, NO 2 , Br, Cl, or OCH 3 ;
B is C 2 to C 8 alkyl or alkenyl; and
C is
optionally substituted with F, Cl, Br, NO 2 , NH 2 , OCH 3 , CH 3 , CO 2 H, or phenyl.
2. The compound of claim 1 wherein C is
Assignments (2)
CONFIRMATORY LICENSE
Recorded Oct 16, 2017
From: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044209/0316 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 8, 2015
From: TIGYI, GABOR; MILLER, DUANE D; PATIL, RENUKADEVI
To: THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
Reel/Frame 035599/0635 →
Continuity (2)
Provisional Application
61693731
· Aug 27, 2012