T-CELL DEATH-INDUCING EPITOPES

1 - 27 . (canceled)

28 . A method of identifying a candidate compound for inducing death of activated T-cells, the method comprising contacting a compound with a polypeptide comprising X 1 -X 2 -X 3 -X 4 -X 5 , wherein

X 1 is Tyr, Trp, His, or Met;

X 2 is Asp;

X 3 is Ser, Phe, Pro, Glu, or His;

X 4 is any amino acid; and

X 5 is Pro, Tyr, His, or Trp,

wherein binding of the compound to the polypeptide indicates that the compound is a candidate for inducing death of activated T-cells.

29 - 31 . (canceled)

32 . The method of claim 28 , wherein the polypeptide is selected from the group consisting of SEQ ID NOs:4 and 6-13.

33 . (canceled)

34 . The method of claim 28 , wherein the compound is an antibody.

35 . The method of claim 34 , wherein the antibody is a monoclonal antibody.

36 . A method of producing an antibody for inducing death of activated T-cells, the method comprising administering to a subject an effective amount of a polypeptide comprising X 1 -X 2 -X 3 -X 4 -X 5 , wherein

X 1 is Tyr, Trp, His, or Met;

X 2 is Asp;

X 3 is Ser, Phe, Pro, Glu, or His;

X 4 is any amino acid; and

X 5 is Pro, Tyr, His, or Trp.

37 - 39 . (canceled)

40 . The method of claim 36 , wherein the polypeptide is selected from the group consisting of SEQ ID NOs:4 and 6-13.

41 . (canceled)

42 . The method of claim 36 , wherein the antibody is a monoclonal antibody.

43 . A method of identifying a candidate compound for inducing death of activated T-cells, the method comprising contacting a compound with a polypeptide comprising X 6 -X 7 -X 8 -X 9 -X 10 , wherein

X 6 is Asp;

X 7 is Tyr, Met, Asn, Trp, or Phe;

X 8 is Phe or Leu;

X 9 is Pro; and

X 10 is Glu,

wherein binding of the compound to the polypeptide indicates that the compound is a candidate for inducing death of activated T-cells.

44 - 46 . (canceled)

47 . The method of claim 43 , wherein the polypeptide is selected from the group consisting of SEQ ID NOs:14-18.

48 . (canceled)

49 . The method of claim 43 , wherein the compound is an antibody.

50 . (canceled)

51 . A method of producing an antibody for inducing death of activated T-cells, the method comprising administering to a subject an effective amount of a polypeptide comprising X 6 -X 7 -X 8 -X 9 -X 10 , wherein

X 6 is Asp;

X 7 is Tyr, Met, Asn, Trp, or Phe;

X 8 is Phe or Leu;

X 9 is Pro; and

X 10 is Glu.

52 - 54 . (canceled)

55 . The method of claim 51 , wherein the polypeptide is selected from the group consisting of SEQ ID NOs:14-18.

56 . (canceled)

57 . The method of claim 51 , wherein the antibody is a monoclonal antibody.

58 . A method of identifying a candidate compound for inducing death of activated T-cells, the method comprising contacting a compound with a polypeptide comprising X 11 -X 12 -X 13 -X 14 , wherein

X 11 is Pro;

X 12 is Met;

X 13 is Glu or Ser; and

X 14 is Ile,

wherein binding of the compound to the polypeptide indicates that the compound is a candidate for inducing death of activated T-cells.

59 - 61 . (canceled)

62 . The method of claim 58 , wherein the polypeptide is selected from the group consisting of SEQ ID NOs:20-22.

63 . (canceled)

64 . The method of claim 58 , wherein the compound is an antibody.

65 . The method of claim 64 , wherein the antibody is a monoclonal antibody.

66 . A method of producing an antibody for inducing death of activated T-cells, the method comprising administering to a subject an effective amount of a polypeptide comprising X 11 -X 12 -X 13 X 14 , wherein

X 11 is Pro;

X 12 is Met;

X 13 is Glu or Ser; and

X 14 is Ile.

67 - 69 . (canceled)

70 . The method of claim 66 , wherein the polypeptide is selected from the group consisting of SEQ ID NOs:20-22.

71 . (canceled)

72 . The method of claim 66 , wherein the antibody is a monoclonal antibody.